Hepatic level of mRNA in relation to polymorphism and strain difference in expression of cytochrome P-450g.
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概要
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Hepatic level of mRNA for P-450g was determined in male and female rats of Sprague-Dawley, ACI and Fischer strains using a specific oligonucleotide probe. The mRNA level in female Sprague-Dawley and Fischer rats was undetectable in accordance with a very low or undetectable level of P-450g protein. The mRNA was detected in all male ACI rats, in which high levels of P-450g protein were detected. In Fischer male rats, mRNA for P-450g was clearly detected in the liver, but P-450g protein was not detected. Moreover, the mRNA was detected in the liver of all male Sprague-Dawley rats, irrespective of the expressed level or absence of P-450g protein. As a most plausible explanation of the observed discordance in the levels of P-450g mRNA and protein, translation of unstable protein for microheterogenous P-450g is discussed.
- 公益社団法人 日本薬理学会の論文
著者
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Nagata Kiyoshi
Department Of Environmental And Health Science Tohoku Pharmaceutical University
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Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University
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Shimada Miki
Department Of Clinical Pharmacy Tohoku University Graduate School Of Pharmaceutical Sciences
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Miyata Masaaki
Department Of Cardiovascular Respiratory And Metabolic Medicine Field Of Cardiovascular And Respiratory Disorders Kagoshima University Graduate School Of Medical And Dental Sciences
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Miyata Masaaki
Department of Cardiology, Respiratory and Metabolic Medicine, Kagoshima University
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NAGATA Kiyoshi
Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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YAMAZOE Yasushi
Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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