THEBAINE METABOLITES IN THE URINE OF RHESUS MONKEYS
スポンサーリンク
概要
- 論文の詳細を見る
The metabolic fate of thebaine in rhesus monkeys was investigated. Using thin layer chromatography, more than four metabolites were detected in the urine of monkeys given thebaine (8 mg/kg, s.c.). Two of the metabolites isolated by high performance liquid chromatography were not consistent with those reported previously. With the use of gas chromatography-mass spectrometry, the structures were identified as oripavine (3-O-demethylthebaine) and nororipavine (3-O, N-di-demethylthebaine) from the mass spectra of their trimethylsilyl and propionyl derivatives. Further experiments with liver microsomes from rhesus monkeys showed that, in addition to these metabolites, northebaine was also formed from thebaine in the presence of NADPH.
- 社団法人 日本薬理学会の論文
著者
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YAMAZOE YASUSHI
Department of Pharmacology, School of Medicine, Keio University
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Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University
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Numata Hiroaki
Departments Of Pharmacology Pathology And Toxicology Central Institute For Experimental Animals
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YANAGITA Tomoji
Department of Pharmacology, Preclinical Research Laboratories, Central Institute for Experimental An
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YAMAZOE Yasushi
Department of Pharmacology, Preclinical Research Laboratories, Central Institute for Experimental Animals
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YANAGITA Tomoji
Department of Pharmacology, Preclinical Research Laboratories
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NUMATA Hiroaki
Department of Pharmacology, Preclinical Research Laboratories, Central Institute for Experimental Animals
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