Expression and Functional Characterization of a Rat Sulfotransferase (ST1A1)cDNA for Sulfations of Phenolic Substrates in COS-1 Cells
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概要
- 論文の詳細を見る
A cDNA (PST-1)isolated from a rat liver cDNA library was expressed in COS-1 cells and found to encode a form of arylsulfotransferase (termed ST1A1), which sulfated <I>p</I>-nitrophenol, α-naphthol, minoxidil, β-estradiol and dopamine, but not dehydroepiandrosterone and cortisol. ST1A1 showed a mobility identical with a major immunodetectable sulfotransferase contained in the livers of male and female rats in Western blots. In addition, ST1A1 mRNA was detected in the liver and extrahepatic tissues by Northern blots.
著者
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NAGATA Kiyoshi
Department of Pharmacology, School of Medicine, Keio University
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Nagata Kiyoshi
Department Of Environmental And Health Science Tohoku Pharmaceutical University
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Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University
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Ozawa Shogo
Department Of Pharmacodynamics And Molecular Genetics School Of Pharmacy Iwate Medical University
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Gong Da-Wei
Department of Pharmacology, School of Medicine, Keio University
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NAGATA Kiyoshi
Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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YAMAZOE Yasushi
Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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