Changes in Cerebral Oxygen Saturation and Blood Flow During Hypoxic Gas Ventilation Therapy in HLHS and CoA/IAA Complex With Markedly Increased Pulmonary Blood Flow
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概要
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Background: Hypoxic gas ventilation therapy has recently been performed to prevent post-birth increased pulmonary blood flow in cases of congenital heart diseases with increased pulmonary blood flow. However, how the oxygen supply to the tissues changes during breathing a hypoxic gas mixture, remains unknown. The changes in cerebral oxygen saturation and blood supply during hypoxic gas ventilation therapy using a nitrogen gas mixture were studied. Methods and Results: Cerebral regional oxygen saturation (cerebral rSO2) was measured by near-infrared spectroscopy, and changes in middle cerebral artery (MCA) blood flow and an index of vascular resistance (RI) were assessed in 8 consecutive patients having congenital heart diseases with increased pulmonary blood flow. In all patients, urinary volume increased significantly, and the respiratory rate showed a clear decrease. Percutaneous oxygen saturation showed no significant change. The average of cerebral rSO2 was 67.3% before hypoxic gas ventilation, but increased to 69.4%, 69.1%, and 70.7% within 1, 12, and 24 h after initiation of treatment, respectively. MCA blood flow significantly increased in the diastolic phase, and RI significantly improved from 0.80 to 0.68 within 12 h after initiation of therapy. Conclusions: These results indicate that hypoxic gas ventilation therapy does not decrease cerebral oxygen saturation, but safely improves the cerebral blood supply in cases of congenital heart diseases with increased pulmonary blood flow.
- 社団法人 日本循環器学会の論文
- 2010-09-25
著者
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KATO Ryuichi
Department of Biology,Graduate School of Science,Osaka University
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Toiyama Kentaro
Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate
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Oka Tatsujiro
Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate
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Kobayashi Naho
Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate
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Noritake Kanae
Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate
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Kawai Yoko
Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate
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Ozawa Seiichiro
Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate
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Nishida Masashi
Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate
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Nishida Masashi
Department Of Applied Chemistry Faculty Of Engineering Sojo University
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Hamaoka Kenji
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Hamaoka Kenji
Department Of Pediatric Cardiology And Nephrology
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Itoi Toshiki
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Itoi Toshiyuki
Department Of Pediatrics Cardiology And Nephrology Graduate School Of Medical Science Kyoto Prefectu
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Itoi Toshiyuki
Department Of Pediatric Cardiology And Nephrology Graduate School Of Medical Science Kyoto Prefectur
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Kato Ryuichi
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Hamaoka Kenji
Department Of Pediatric Cardiology And Nephrology Graduate School Of Medical Science Kyoto Prefectur
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Itoi Toshiyuki
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Hamaoka Kenji
Department Of Pediatrics Cardiology And Nephrology Graduate School Of Medical Science Kyoto Prefectu
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Ozawa Seiichiro
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Nishida Masashi
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Kawai Yoko
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Oka Tatsujiro
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Noritake Kanae
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Kobayashi Naho
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Toiyama Kentaro
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Ozawa Sei-ichiro
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Hamaoka Kenji
Department Of Pediatric Cardiology And Nephrology Graduate School Of Medical Science Kyoto Prefectur
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Hamaoka Kenji
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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Toiyama Kentarou
Department Of Pediatric Cardiology And Nephrology Kyoto Prefectural University Of Medicine Graduate
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