Dexamethasone Inhibits Nitric Oxide Synthase mRNA Induction by Interleukin-1.ALPHA. and Tumor Necrosis Factor-.ALPHA. in Vascular Smooth Muscle Cells.
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概要
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ABSTRACT-The effects of interleukin-1α, tumor necrosis factor-α and dexamethasone on the induction of nitric oxide synthase mRNA in rat aortic smooth muscle cells were studied. Neither interleukin-1α (up to 100 U/ml) nor tumor necrosis factor-α (up to 5000 U/ml) was capable of inducing nitrite/nitrate production and nitric oxide synthase mRNA in smooth muscle cells. In contrast, treatment for 12 hr or longer with a combination of the two synergistically induced nitrite/nitrate and cyclic GMP production in cell culture media and nitric oxide synthase mRNA, both of which were prevented by dexamethasone. Contamination with bacterial lipopolysaccharide, which may affect the induction of nitric oxide synthase, was below 30 pg/ml in all experiments. Our findings show that dexamethasone and these cytokines regulate the induction of nitric oxide synthase at the mRNA level in vascular smooth muscle cells.
- 公益社団法人 日本薬理学会の論文
著者
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Nagata Kiyoshi
Department Of Environmental And Health Science Tohoku Pharmaceutical University
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Marumo Takeshi
Department Of Clinical Renal Regeneration Graduate School Of Medicine And Faculty Of Medicine The Un
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Nakaki Toshio
Department Of Pharmacology Keio University School Of Medicine
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Saruta Takao
Department Of Clinical Pharmacology Jichi Medical School
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Suzuki Hiromichi
Department Of Applied Physics Faculty Of Science Fukuoka University
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Esumi Hiroyasu
Biochemistry Division National Cancer Center Research Institute
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Miyata Masaaki
Department Of Cardiovascular Respiratory And Metabolic Medicine Field Of Cardiovascular And Respiratory Disorders Kagoshima University Graduate School Of Medical And Dental Sciences
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Adachi Hiroko
Biochemistry Division, National Cancer Center Research Institute
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Miyata Masaaki
Department of Cardiology, Respiratory and Metabolic Medicine, Kagoshima University
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Miyata Masaaki
Departments of Pharmacology, Keio University School of Medicine
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NAGATA Kiyoshi
Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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Kato Ryuichi
Departments of Pharmacology, Keio University School of Medicine
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