Regulations of Male-Dominant P-450Md mRNA in Rat Liver by Hormonal Factors and Xenobiotics.
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概要
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Male-dominant P-450Md mRNA was undetectable in the livers of newborn rats. In female rat livers, the mRNA appeared at 17 days of age and then decreased to very low levels in the adult periods. The level of P-450Md mRNA in female rats was increased by phenobarbital or dexamethasone treatment, whereas the level in the males was depressed by methylcholanthrene. Hypophysectomy decreased the level of P-450Md mRNA in male rat livers, and continuous infusion or twice-daily injections of growth hormone to hypophysectomized rats caused further suppression or clear restoration, respectively, of the mRNA level.
- 公益社団法人 日本薬理学会の論文
著者
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Nagata Kiyoshi
Department Of Environmental And Health Science Tohoku Pharmaceutical University
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Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University
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Shimada Miki
Department Of Clinical Pharmacy Tohoku University Graduate School Of Pharmaceutical Sciences
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NAGATA Kiyoshi
Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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YAMAZOE Yasushi
Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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