Effect of Adrenalectomy on the Substrate Interaction with Cytochrome P-450 in the Hydroxylation of Steroid Hormones by Liver Microsomes
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概要
- 論文の詳細を見る
Adrenalectomy in male rats slightly decreased cytochrome P-450 content in liver microsomes. The magnitude of testosterone-induced spectral change and the hydroxylating activity for testosterone by liver microsomes were markedly decreased to a similar extent in adrenalectomized male rats. Similar results were obtained, when progesterone was used as the substrate. The magnitude of testosterone-or progesteroneinduced spectral change per unit of P-450 was also decreased in the adrenalectomized males. These results suggest that the binding capacity of cytochrome P-450 for testosterone or progesterone was decreased after adrenalectomy.<BR>In contrast to the results obtained with male rats, the binding capacity of cytochrome P-450 and the hydroxylating activity for testosterone or progesterone were not significantly decreased in the adrenalectomized females. Similarly, the binding capacity of P-450 and the hydroxylating activity for testosterone or progesterone were not significantly decreased by adrenalectomy in castrated male rats and male and female mice. However, adrenalectomy in castrated and testosterone-treated male rats produced the effects similar to those observed in the intact male rats.<BR>These results indicate that the action of androgen to increase the binding capacity of cytochrome P-450 for steroid hormone was impaired in the adrenalectomized rats and consequently the hydroxylating activity for steroid hormones by liver microsomes was decreased.
- 社団法人 日本内分泌学会の論文
著者
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Omori Yoshihito
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Takahashi Atsushi
Department Of Cardiology Akita City General Hospital
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ONODA Kin-ichi
Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Scienc
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Takahashi Atsushi
Departmant Of Surgery(i) Kanazawa University School Of Medicine
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