Virilizing Effect of Methyltestosterone on Female Descendants in the Rat
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概要
- 論文の詳細を見る
Pregnant rats were given daily a subcutaneous injection of methyltestosterone for 4 days from the 17th to the 20th day of gestation, and were allowed to be delivered to their offprings (F<SUB>1</SUB>) which were used for the examimation of later reproductive functioning. When observed for 21 weeks after birth, the growth rate of F<SUB>1</SUB> from methyltestosterone-treated groups was higher than that of F<SUB>1</SUB> from the control group. The anogenital distance in 50-μg-treated F<SUB>1</SUB> females started to become significantly longer on the 14th day and in 5μg-treated F<SUB>1</SUB> females on the 28th day after birth than that in F<SUB>1</SUB> from the control. The day on which vaginal opening took place in 50% of females was 34.4 days of age in both the control and the 5μg groups, but it delayed until 40.7 days in the 50μg group. Furthermore, persistent estrus was observed after about 90 days of age in the 50μg group. This persistent estrus disappeared by placing these females with males, resulting no pregnancy. In the 5μg group females could be pregnant, but their female fetuses (F<SUB>2</SUB>), when examined on the 21st day of gestation, had significantly shortened the length of the urovaginal septum. The observations show that virilization can be induced in the third generation.
- 社団法人 日本内分泌学会の論文
著者
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Tanaka Satoru
Department Of Cardiovascular Medicine Gifu Pref. Govt. Tajimi Hospital
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Kawashima Kunio
Division Of Pharmacology National Institute Of Hygienic Sciences
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Omori Yoshihito
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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KAWASHIMA Kunio
Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Scienc
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NAKAURA Shinsuke
Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Scienc
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NAGAO Shigeyuki
Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Scienc
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Kuwamura Tsukasa
Department Of Pharmacology National Institute Of Hygienic Sciences
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Tanaka Satoru
Department Of Anesthesiology Sapporo Medical University School Of Medicine
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Kawashima Kunio
Department Of Pathology National Institute Of Health Sciences
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