Suppressive Effect of Dexamethasone on Morphine-Induced Adrenocorticoidogenesis in Rat
スポンサーリンク
概要
- 論文の詳細を見る
The effect of morphine on adrenal-pituitary axis function was examined by determination of adrenal and serum corticosterone changes in rats pretreated with dexamethasoe.<BR>Increases in both adrenal and serum corticosterone concentrations induced by a single dose of 20mg/Kg of morphine were almost completely inhibited by subcutaneous injection with 1mg/rat of dexamethasone 3 hr prior to morphine administration. However, no suppressive effect of dexamethasone was observed when a dose of 30μg/rat of synthetic ACTH was given.<BR>In morphinized rats, adrenal and serum corticosterone concentrations were not so significantly increased as observed in a single dose of morphine administration. However, corticosterone concentrations after the morphinization were increased strikingly by synthetic ACTH or nalorphine administration immediately after the final treatment of morphine. But these increases after nalorphine administration were inhibited entirely by the pretreatment with dexamethasone.<BR>On the bases of these findings, it was suggested that morphine dose not act directly corticoidogenesis in adrenal cortex but affects through the central nervous system.
- 社団法人 日本内分泌学会の論文
著者
-
Tanaka Satoru
Department Of Cardiovascular Medicine Gifu Pref. Govt. Tajimi Hospital
-
Nakao Takeshi
Department Of Electrical And Information Systems Osaka Prefecture University
-
Omori Yoshihito
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
KAWASHIMA Kunio
Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Scienc
-
NAKAURA Shinsuke
Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Scienc
-
NAGAO Shigeyuki
Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Scienc
-
Kuwamura Tsukasa
Department Of Pharmacology National Institute Of Hygienic Sciences
-
Tanaka Satoru
Department Of Anesthesiology Sapporo Medical University School Of Medicine
-
Kawashima Kunio
Department Of Pathology National Institute Of Health Sciences
関連論文
- Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
- Anion Ordering Transition in (TMTSF)_2ClO_4 under Pressure
- Interval Representative of Transmural Dispersion of Repolarization in Children and Young Adolescents With Congenital Long QT Syndrome
- Predictive Factors in the Success of Intervention to Treat Obesity in Elementary School Children
- MECHANISTIC STUDY ON INHIBITION OF SERUM THYROID HORMONE PRODUCTION BY THIOUREA
- THYROID PROLIFERATIVE LESIONS INDUCED BY ANTI-THYROID DRUGS IN RATS ARE NOT ALWAYS ACCOMPANIED BY SUSTAINED INCREASES IN SERUM TSH
- EFFECT OF PHOSPHORIC ACID TRI-ESTERS FLAME RETARDANTS ON THE PRENATAL AND POSTNATAL DEVELOPMENTS OF THE RATS
- P-PW-08 SELECTIVE AND IN-SITU DETERMINATION OF CARBONATE AND OXIDE PARTICLES IN AQUEOUS SOLUTION USING LASER-INDUCED BREAKDOWN SPECTROSCOPY (LIBS) FOR WEARABLE INFORMATION EQUIPMENT
- On the Estimation of Carrier Frequency Offset and DC Offset for OFDM Systems
- STUDY ON THE SPERM MOTILITY, COUNT OR MORPHOLOGICAL CHANGE AND MALE FERTILITY DISTURBANCE INDUCED BY CHEMICALS
- PJ-523 Adiponectin Predicts Cardiac Mortality and Left Ventricular Dysfunction after Acute Myocardial Infarction(PJ088,ACS/AMI (Clinical/Pathophysiology) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Soci
- PJ-037 The Relationship between Rate of Change of HDL Cholesterol and Cardiac Events in Patients Taking Strong Statins after Elective PCI(PJ006,Lipid Disorders (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation So
- PE-544 Associations of Genetic Variants with Myocardial Infarction in Japanese Individuals with Chronic Kidney Disease(PE091,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-214 Statin and Angiotensin-Converting Enzyme Inhibitor Improve Endothelial Cell Function in Patients after Acute Myocardial Infarction(OJ36,Peripheral Circulation/Vascular Disease (Therapy) 2 (H),Oral Presentation (Japanese),The 73rd Annual Scientific
- OJ-164 Association of a Polymorphism of the Apolipoprotein E Gene with Chronic Kidney Disease in Japanese Individuals with Metabolic Syndrome(OJ28,Kidney/Renal Circulation/CKD 1 (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Ja
- OJ-163 Association of Genetic Variants with Chronic Kidney Disease in Japanese Individuals(OJ28,Kidney/Renal Circulation/CKD 1 (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-127 Matrix Metalloproteinase-2 Predicts Cardiac Mortality and Heart Failure Hospitalization after Acute Myocardial Infarction(OJ22,ACS/AMI (Clinical/Pathophysiology) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- OE-203 Identification of Polymorphisms of the Apolipoprotein A-V Gene as Genetic Risk Factors for Metabolic Syndrome(OE35,Metabolic Syndrome (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Electroluminescence in AlGaN/GaN High Electron Mobility Transistors under High Bias Voltage (Short Note)
- Does B-Type Natriuretic Peptide Predict the New Onset of Hypertension?
- Metabolic Disorders Predict Development of Hypertension in Normotensive Japanese Subjects
- PJ-839 Metabolic Syndrome and Its Components Increase Carotid Intima-Media Thickness(Diabetes / Obesity / Metabolic syndrome(15)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-650 Abnormalities in Metabolic Factors Predict Future Development of Hypertension in Normotensive Subjects(Hypertension, clinical-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-645 Increased Pulse Wave Velocity Predicts Future Development of Hypertension in Normotensive, Middle-aged Male Subjects(Hypertension, clinical-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Observation of Surface Water on Various Materials by AFM and XPS
- Defect Formation during Hetero-Epitaxial Growth of Aluminum Nitride Thin Films on 6H-Silicon Carbide by Gas-Source Molecular Beam Epitaxy
- Application of ζ-factor method to Ti-Al-Cr system in analytical electron microscopy
- Plasma Brain Natriuretic Peptide Levels Predict Future Development of Hypertension in Healthy Male Japanese (Preventive Medicine/Epidemiology/Education/Health Policy 5 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 99mTc-Sestamibi Scintigraphy in the Prediction of Cardiac Events in Patients with Congestive Heart Failure(Nuclear Cardiology 6 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Selective Reduction of NO with Propane on Gallium Ion-exchanged Zeolites
- Isotopic Effect on Thermal Physical Properties of Isotopically Modified Boron Single Crystals
- Thermal Conductivity of Isotopically Enriched β-Rhombohedral Boron
- Multifocal osteomyelitis due to Bartonella henselae in a child without focal pain
- Silicate Anion Structural Change in Calcium Silicate Hydrate Gel on Dissolution of Hydrated Cement
- Deposition Behavior of Polystyrene Latex Particles on Solid Surfaces during Migration through an Artificial Fracture in a Granite Rock Sample
- Dissolution Phenomena of CaO-SiO_2-H_2O Gel at Ca/Si>1 Coexisting with Ettringite System
- Measurement of Rotational Populations of CH Radicals in Low-Temperature Plasmas
- COMPARISONS OF THE TOXICOKINETIC PARAMETERS IN RATS DETERMINED FOR LOW AND HIGH DOSE OF γ-CHLORDANE
- FETAL TOXICITY OF ZINC ETHYLPHENYLDITHIOCARBAMATE(ZEPC)(3). MECHANISM OF FORMATION OF METHEMOGLOBIN CAUSED BY ZEPC
- INFLUENCE OF DOSE ON THE TOXICOKINETICS OF γ-CHLORDANE
- Respiratory and cardiovascular effects of fentanyl during propofol-induced sedation under spinal anesthesia
- Effects of reduction of carrier gas flow rate on sevoflurane and isoflurane consumption and costs
- STUDIES ON THE ESTABLISHMENT OF APPROPRIATE SPERMATOGENIC ENDPOINTS FOR MALE FERTILITY DISTURBANCE IN RODENT INDUCED BY DRUGS AND CHEMICALS I. NITROBENZENE
- STUDY OF EXAMINATION METHODS FOR ASSESSING MALE FERTILITY DISTURBANCES 2.THE SPERM EVALUATION USING ADRIAMYCIN
- EFFECTS OF DEPLETION OF EMBRYONIC GLUTATHIONE ON SELENIUM TERATOGENICITY IN CULTURED RAT EMBRYOS
- Experimental Evaluation of Predissociation Rate in v=4 State Usable for Analysis of H_2 Fulcher-α Band Emission(Gases, Plasmas and Electric Discharges)
- EFFECTS OF TRIS (2, 3-DIBROMOPROPYL) PHOSPHATE ON THE PRENATAL AND POSTNATAL DEVELOPMENTS OF THE RATS (The 6th Meeting for the Study of Toxic Effect)
- STUDIES ON THE TERATOGENICITY OF FURYLFURAMIDE IN FETUSES AND OFFSPRING OF RATS IN RELATION TO FETAL DISTRIBUTION
- High-resolution MR lymphography using ultrasmall superparamagnetic iron oxide (USPIO) in the evaluation of axillary lymph nodes in patients with early stage breast cancer : preliminary results
- A-15 IN VITRO TERATOGENICITY TESTING USING THE RAT EMBRYO CULTURE SYSTEM : (3) EFFECTS OF CYCLOPHOSPHAMIDE ON RAT EMBRYONIC DEVELOPMENT IN VITRO AND IN VIVO
- A-6 EFFECT OF BIS (TRIBUTYLTIN) PHTHALATE ON THE FETAL DEVELOPMENT
- C12 IN VITRO TERATOGENICITY TESTING USING THE RAT EMBRYO CULTURE SYSTEM : (1) EFEECTS OF SODIUM SALICYLATE ON RAT EMBRYONIC DEVELOPMENT IN VITRO AND IN VIVO
- C03 SYNERGIC EFFECT OF MESTRANOL ON VIRILIZING ACTIVITY OF NORETHYNODREL IN FEMALE RAT FETUSES
- EFFECT OF INTRAMUSCULAR INJECTION OF DRUGS ON SERUM CPK ACTIVITY IN RABBITS
- TERATOLOGICAL STUDIES OF ZINC ETHYLPHENYLDITHIOCARBAMATE (ZEPC), A VULCANIZATION ACCELERATOR FOR RUBBERS, IN RATS
- A FORM OF CYTOCHROME P-450 WITH HIGH SPECIFICITY FOR AFLATOXIN B_1. ITS PURIFICATION AND SPECIES SPECIFICITY
- 218 EFFECTS OF 2- AND 3-CHLORODIBENZOFURANS ON THE DEVELOPMENT OF CULTURED POSTIMPLANTATION RAT EMBRYOS
- Haldane to Dimer Phase Transition in the Spin-1 Haldane System with Bond-Alternating Nearest-Neighbor and Uniform Next-Nearest-Neighbor Exchange Interactions
- DRUG AFFECTING THE GASTRIC EMPTYING RATE AND DRUG ABSORPTION
- Mechanism of Thyroxine-induced Increase in Steroid Δ4-Reductase Actiyity in Male Rats
- Effect of Adrenalectomy on the Substrate Interaction with Cytochrome P-450 in the Hydroxylation of Steroid Hormones by Liver Microsomes
- POSSIBLE CONVERSION OF ANDROST-4-ENE-3β, 17β, 19-TRIOL TO ESTRIOL IN VITRO IN RAT TESTIS
- DOUBLE ISOTOPE DERIVATIVE ASSAY OF ESTRADIOL-17β AND ESTRIOL: PRELIMINARY STUDY ON PIPSYLATION OF ESTROGEN AND ACETYLATION OF PIPSYLATED ESTROGEN
- CONVERSION OF 4-ANDROSTENEDIOL AND 5-ANDROSTENEDIOL TO TESTOSTERONE, AND CONVERSION OF DEHYDROEPIANDROSTERONE TO 4-ANDROSTENEDIOL BY RAT TESTIS IN VITRO
- Effect of Xylitol on Testicular Protein and RNA Biosynthesis of Rats
- STUDIES ON CYCLIC NUCLEOTIDES IN THE ADRENAL GLAND : II. PROPERTIES OF CYCLIC AMP DEPENDENT PROTEIN KINASES IN THE ADRENAL GLAND
- Ab Initio Calculations for the Substitutions of Al(OH)^-_4 and SO^_4 with Si Tetrahedra
- Trapping and Detrapping Mechanisms of Deuterium in SiC Studied by XPS and TDS Techniques
- EFFECT OF PHENYLPYRAZOLONE DERIVATIVES ON GASTRIC EMPTYING RATE AND DRUG ABSORPTION IN RATS
- Gramian-Preserving Frequency Transformation for Linear Discrete-Time State-Space Systems
- Virilizing Effect of Testosterone and Its Metabolites on the Urovaginal Septum of Female Fetal Rats
- Virilizing Effect of Methyltestosterone on Female Descendants in the Rat
- Virilizing Activities of Various Steroids in Female Rat Fetuses
- Differentiation of Urovaginal Septum and its Critical Period of Abridgment by Testosterone in Female Rat Fetuses
- Quantitative Evaluation of Virilizing Activity of Steroids by Measuring Morphological Changes in Uro-genital Region of Rats
- EFFECT OF MORPHINIZATION ON IN VITRO INCORPORATION OF LABELLED PRECURSORS INTO ADRENAL PROTEIN AND NUCLEIC ACIDS IN RATS
- Suppressive Effect of Dexamethasone on Morphine-Induced Adrenocorticoidogenesis in Rat
- Quantum Chemical Calculation of O-H Vibration in LiOH Ab-initio Analysis of Hydrogen Isotopes in Ceramic Breeder Materials
- Compatibility Test of AIN with Liquid Lithium under Nitrogen Control
- Dependence of the Nuclear Excitation by Electron Transition on the Decay Rate
- Compatibility of SiC/SiC Composite Materials with Molten Lithium Metal and Li16-Pb84 Eutectic Alloy
- Effect of Androgen and Estrogen on the Hydroxylation of Steroid Hormones by Rat Liver Microsomes
- International Harmonization of Reproductive and Developmental Toxicity Studies
- Site-Specific Stereograph of SiC(0001) Surface by Inverse Matrix Method
- Electrical Characteristics of Surface-Stoichiometry-Controlled p-GaN Schottky Contacts
- Development of Laser Photodetachment Technique Using Heated Probe to Eliminate the Effect of Probe Surface Ablation Phenomena
- Alterations of Ovarian 4-Pregnen-20α-ol-3-one and Adrenal Corticosterone at Various Times after Hypophysectomy, and the Ovarian Response to Exogenous Pituitary Gonadotropin
- Graphene Nanoribbons Grown on Epitaxial Si
- Acute Effect of Morphine Administration on Secretion of Adrenal Corticosterone in Rats
- Microfluorometric Determination of 4-Pregnen-20α-ol-3-one Separated from Rat Ovarian Venous Blood and Ovary by Divided Thin Layer Chromatography
- Foveal sparing in patients with Japanese Stargardt's disease and good visual acuity
- Measurement of Gas Composition Ratio of H-He Mixture Plasmas in Divertor Simulator MAP-II
- Measurement of Rotational Populations of CH Radicals in Low-Temperature Plasmas
- A METHOD OF ASSAYING ADRENAL CORTICAL HORMONES BASED ON A DECREASE IN THE CIRCULATING LYMPHOCYTES OF HYPOPHYSECTOMIZED RATS (LYMPHOPENIA METHOD)
- Defect Formation during Hetero-Epitaxial Growth of Aluminum Nitride Thin Films on 6H-Silicon Carbide by Gas-Source Molecular Beam Epitaxy