EFFECT OF MORPHINIZATION ON <I>IN VITRO</I> INCORPORATION OF LABELLED PRECURSORS INTO ADRENAL PROTEIN AND NUCLEIC ACIDS IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
<I>In vitro</I> incorporation of radioactive precursors into protein or nucleic acids and corticosterone production in the adrenals of morphine treated rats were examined, and the results were compared with those of ACTH treatment. An increase in incorporation of radioactive precursors into nucleic acids with concomitant decrease in corticosterone production was observed with repeated morphine treatment, indicating an enhanced synthesis of nucleic acids in the glands. On the other hand, incorporation of labelled amino acids into protein decreased after an initial increase. With repeated ACTH treatment, decreased incorporation of labelled precursors was observed in both protein and nucleic acids in parallel with the gradual increase in the rate of corticosterone production during the course of ACTH treatment. When adrenals were incubated with 5 μg/flask of corticosterone, the incorporation of radioactive precursors into nucleic acids was decreased markedly. These results suggest an interference of corticosterone which accumulates in the medium with the synthesis of nucleic acids <I>in vitro</I>.
- 社団法人 日本薬理学会の論文
著者
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Tanaka Satoru
Department Of Cardiovascular Medicine Gifu Pref. Govt. Tajimi Hospital
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Nakao Takeshi
Department Of Electrical And Information Systems Osaka Prefecture University
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Omori Yoshihito
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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KAWASHIMA Kunio
Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Scienc
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NAKAURA Shinsuke
Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Scienc
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NAGAO Shigeyuki
Department of Pharmacology, Biological Safety Research Center, National Institute of Hygienic Scienc
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Kuwamura Tsukasa
Department Of Pharmacology National Institute Of Hygienic Sciences
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Tanaka Satoru
Department Of Anesthesiology Sapporo Medical University School Of Medicine
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Kawashima Kunio
Department Of Pathology National Institute Of Health Sciences
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NAGAO SHIGEYUKI
Department of Pharmacology, National Institute of Hygienic Sciences
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KUWAMURA TSUKASA
Department of Pharmacology, The Jikei University School of Medicine
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NAKAURA SHINSUKE
Department of Pharmacology, National Institute of Hygienic Sciences
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