Activation of Phorbol Ester Responsive Form of Protein Kinase CC in Association with Ca^<2+> : Induced Differentiation of Primary Cultured Mouse Epidermal Cells
スポンサーリンク
概要
- 論文の詳細を見る
In primary cultured mouse epidermal cells, protein kinase C (PKC) ζconsists of multiple forms: a low salt-eluted PKCζ (1-PKCζ, 79 and 85 kDa) and a high salt-eluted PKCC (h-PKCζ, 79 and 85 kDa) by anion-exchange column chromatography (K. Nishikawa et al., Cell. Signal. 7, 491-504, 1995). In the present study, PKC isozyme-specific responses during terminal differentiation of epidermal cells, which were induced by the increase of Ca<SUP>2+</SUP> -concentration in culture medium, were examined. After 24 hr-treatment with 1.8 mM Ca<SUP>2+</SUP>, 79-kDa 1-PKCζ in the particulate fraction was apparently shifted to the 85-kDa form. The phosphatidylserine-dependent kinase activity of this 1-PKCζ was increased in association with the shift. These results suggest the pivotal role of 1-PKCζ in the particulate fraction in the Ca<SUP>2+</SUP> -induced epidermal cell differentiation processes.
- 社団法人 日本薬理学会の論文
- 1997-02-01
著者
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Yamamoto Satoshi
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Nishikawa Kiyotaka
Department Of Clinical Pharmacology Research Institute International Medical Center Of Japan:presto
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Nishikawa Kiyotaka
Department Of Pharmacology School Of Medicine Keio University
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NAGUMO Haruna
Department of Pharmacology, School of Medicine, Keio University
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Nagumo Haruna
Department Of Pharmacology School Of Medicine Keio University
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Yamamoto Satoshi
Department Of Biochemistry Nagoya University School Of Medicine
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