PARTIAL AGONISTIC ACTION OF MORPHINE IN THE RAT VAS DEFERENS
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概要
- 論文の詳細を見る
Effects of morphine on the force of contraction of rat vas deferens were investigated. Morphine and β-endorphin decreased the electrically evolved tvvitch tension, in a close dependent manner. The inhibitory effect of morphine, however, was much weaker than that of β-endorphin. These effects of both morphine and β-endorphin were completely antagonized by naloxone. In the presence of 30 μM morphine, the dose-response curve of β-endorphin shifted to the right by about 10-fold. Moreover, morphine partly reversed the contraction depressed by 0.3 μM β-endorphin, in a dose dependent manner. These findings suggest that morphine acts as a partial agonist on the rat vas deferens. Marked tolerance to β-endorphin and change in the antagonist potency of morphine were not observed in the vas deferens isolated from morphine-dependent rats.
- 社団法人 日本薬理学会の論文
著者
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Yamamoto Satoshi
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Muraki Takamura
Department Of Pharmacology Tokyo Women's Medical College
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Ishii Kunio
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Yamamoto Satoshi
Department Of Biochemistry Nagoya University School Of Medicine
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ISHII Kunio
Department of Pharmacology, School of Medicine, Keio University
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MURAKI TAKAMURA
Department of Dermatology, School of Medicine, Keio University
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