PARTIAL AGONISTIC ACTION OF MORPHINE IN THE RAT VAS DEFERENS

スポンサーリンク

概要

• 論文の詳細を見る

• Effects of morphine on the force of contraction of rat vas deferens were investigated. Morphine and β-endorphin decreased the electrically evolved tvvitch tension, in a close dependent manner. The inhibitory effect of morphine, however, was much weaker than that of β-endorphin. These effects of both morphine and β-endorphin were completely antagonized by naloxone. In the presence of 30 μM morphine, the dose-response curve of β-endorphin shifted to the right by about 10-fold. Moreover, morphine partly reversed the contraction depressed by 0.3 μM β-endorphin, in a dose dependent manner. These findings suggest that morphine acts as a partial agonist on the rat vas deferens. Marked tolerance to β-endorphin and change in the antagonist potency of morphine were not observed in the vas deferens isolated from morphine-dependent rats.

• 社団法人 日本薬理学会の論文

著者

• Kato Ryuichi

  Department Of Biology Graduate School Of Science Osaka University

• Yamamoto Satoshi

  Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science

• Muraki Takamura

  Department Of Pharmacology Tokyo Women's Medical College

• Ishii Kunio

  Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences

• Yamamoto Satoshi

  Department Of Biochemistry Nagoya University School Of Medicine

• ISHII Kunio

  Department of Pharmacology, School of Medicine, Keio University

• MURAKI TAKAMURA

  Department of Dermatology, School of Medicine, Keio University

関連論文

• Crystallization and Preliminary X-Ray Crystallographic Studies of Thermus thermophilus HB8 MutM Protein Involved in Repairs of Oxidative DNA
• Nitric oxide contributes to irreversible membrane dysfunction caused by experimental ischemia in rat hippocampal CA1 neurons
• MACROMOLECULAR BINDING OF CARCINOGENIC/MUTAGENIC N- HYDROXYARYLAMINES THROUGH O-ACETYLATION PATHWAY
• MECHANISM OF MUTATION AND METABOLIC ACTIVATION OF NITRO-, NITROSO-, HYDROXYLAMINO-COMPOUNDS IN NITRO-COMPOUNDS RESISTANT MUTANTS OF AMES TESTAR STRAIN (TA98NR, TA98/1,8-DNP_6)
• Integral Value of JT Interval in Magnetocardiography is Sensitive to Coronary Stenosis and Improves Soon After Coronary Revascularization
• PJ-254 'Injury Current' in Patients with coronary Stenosis Can be Visualized by Magnetocardiography, and Continues to Exist Early after Coronary Revascularization(Myocardial ischemia/reperfusion, basic/clinical-4, The 71st Annual Scientific Meeting of the
• PE-151 Detection of the 'Injury Current' of Ischemic Myocardium by High-Tc-SQUID Magnetocardiography(ECG/Body surface potential mapping/Holter-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PE-358 Current-arrow Map of Magnetocardiography is Highly Sensitive to Coronary Stenosis, and Can Visualize the 'Injury Current' of Ischemic Myocardium(ECG/Body surface potential mapping/Holter-4 (A) PE60,Poster Session (English),The 70th Anniversary Annu
• OE-087 Diagnosis of Coronary Stenosis by Multiple-Current-Vector Diagram of Magnetocardiography : A Novel Technique to Evaluate the Inhomogeneity of Myocardial Repolarization(ECG/Body surface potential mapping/Holter-1 (A) OE15,Oral Presentation (English)
• Detection of the Patients with Coronary Stenosis by High-Tc-SQUID Magnetocardiogram(ECG/Body Surface Potential Mapping/Holter 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Mutation Site Dependent Variability of Cardiac Events in Japanese LQT2 Form of Congenital Long-QT Syndrome
• A Novel Mutation Associated With Jervell and Lange-Nielsen Syndrome in a Japanese Family
• OJ-009 A Common KCNE1 Polymorphism, D85N, is a Genetic Modifier of Long QT Syndrome(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Modulation of Ethanol-Mediated CYP2E1 Induction by Clofibrate and L-Carnitine in Rat Liver
• PJ-149 Pravastatin administration reduces contrast-induced nephropathy(Kidney/Renal circulation(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• Formation of 2-Amino-3-methylimidazo[4,5-f]quinoline- and 2-Amino-3, 8-dimethylimidazo[4,5-f]quinoxaline-sulfamates by cDNA-expressed Mammalian Phenol Sulfotransferases
• CLONING, EXPRESSION, AND FUNCTIONAL CHARACTERIZATION OF RAT AND HUMAN PHENOL SULFOTRANSFERASES
• RAT LIVER SULFOTRANSFERASE ACTIVATING CARCINOGENIC HYDROXYMETHYL-ARENES : ITS PROPERTIES AND SEQUENCE ANALYSIS OF cDNA
• Cord blood transplantation with a reduced-intensity conditioning regimen for patients with relapsed aggressive multiple myeloma after cytoreduction with bortezomib
• A 350 GHz SIS Receiver on the Nobeyama 10m Submillimeter Telescope
• MECHANISM OF THE CHANGES IN HEPATIC DRUG METABOLIZING ENZYMES IN DIABETIC STATES
• REGULATION AND CHARACTERIZATION OF STEROID 6β-HYDROXYLASE IN RAT LIVERS
• ROLE OF GROWTH HORMONE ON THE EXPRESSION OF SEX-SPECIFIC FORMS OF CYTOCHROME P-450,P-450-MALE AND P-450-FEMALE
• STUDIES ON SEX-SPECIFIC FORMS OF CYTOCHROME P-450 IN MALE AND FEMALE RATS
• Knotting of two central venous catheters : a rare complication of pulmonary artery catheterization
• 小腸嵌入型 Chilaiditi 症候群に対し腹腔鏡補助下回腸部分切除術を施行した1例
• Single Solitary Metastasis of the Slowly Progressive Type of Renal Cell Carcinoma to the Choroid Plexus : Case Report
• PJ-190 A KCNE1 Single Nucleotide Polymorphism, D85N, Serves as a Modifier in Forme-fruste Type of Long QT syndrome(Genetics/Genetically engineered models/Gene therapy-3 (M) PJ32,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of t
• OJ-349 High Incidence of Cardiac Events for Long-QT Syndrome with Compound Mutations(Arrhythmia, diagnosis/pathophysiology/EPS-4 (A) OJ59,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-064 Age-Related Triggers for Life-Threatening Arrhythmia in Genotyped Long-QT Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-3 (A) OJ11,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-483 Increasing Skeletal Muscle Power Decrease Enhanced Activity of Sympathetic Nerve as Central Chemoreflex in Patients with Old Myocardial Infarction(Exercise Test/Cardiac Rehabilitation 5 (IHD) : PJ81)(Poster Session (Japanese))
• PJ-473 Suboptimal Glycemic Control Associates with Stent Restenosis after Coronary Stenting(Coronary Revascularization, PTCA/Stent/DCA/Rotablator/New Device 12 (IHD) : PJ79)(Poster Session (Japanese))
• An Aspartate Aminotransferase from an Extremely Thermophilic Bacterium, Thermus thermophilus HB8^1
• Clinical course linkage among different priapism subtypes : Dilemma in the management strategies
• Crystal Structure of Thermus thermophilus HB8 UvrB Protein, a Key Enzyme of Nucleotide Excision Repair
• Cloning and characterization of the radA gene from a hyperthermophilic archaeon Pyrobaculum islandicum.
• Quantitative Analysis of Three-dimensional Fatigue Fracture Surface Reconstructed by Stereo Matching Method
• Automated Image Processing and Analysis of Fracture Surface Patterns Formed during Creep Crack Growth in Austenitic Heat-Resisting Steels with Different Microstructures
• STEREOSELECTIVE HYDROXYLATION OF MEPHENYTOIN IN HUMAN LIVERS : CLONING AND EXPRESSION OF MEPHENYTOIN HYDROXYLASE cDNAS IN YEASTS AND THE GENETIC POLYMORPHISM
• S-5 CURRENT TOPICS OF SPECIES SPECIFICITY IN DRUG TOXICITY-METABOLIC ASPECT
• Changes in Cerebral Oxygen Saturation and Blood Flow During Hypoxic Gas Ventilation Therapy in HLHS and CoA/IAA Complex With Markedly Increased Pulmonary Blood Flow
• TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448
• The Role of Glutathione in the Activation and Detoxication of a Naturally Occurring Mutagen-Carcinogen, Trp-P-2 (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
• MECHANISMS INVOLVED IN THE COVALENT BINDING OF A TRYPTOPHAN-PYROLYSATE PROMUTAGEN, TRP-P-2,TO DNA
• STUDIES ON CYTOCHROME P-450 RESPONSIBLE FOR THE OCCURRENCE OF SEX DIFFERENCE OF DRUG METABOLISM IN THE RAT
• A SENSITIVE METHOD FOR THE DETERMINATION OF BIPHENYL HYDROXYLASE ACTIVITY AND IT'S TOXICOLOGICAL APPLICATION
• MECHANISMS OF METABOLIC ACTIVATION OF A TRYPTOPHAN PYROLYSATE, 3-AMINO-1-METHYL-5H-PYRIDO [4,3-b] INDOLE
• PURIFICATION AND PROPERTIES OF CYTOCHROME P-450 AND NADPH-CYTOCHROME C (P-450) REDUCTASE FROM MICROSOMES OF HUMAN LIVERS
• STUDIES ON THE METABOLIC ACTIVATION AND THE MECHANISM OF TOXICITY OF DRUGS V. REDUCTION OF N-HYDROXY DERIVATIVE OF AN AROMATIC AMINE, 2-ACETYLAMINOFLUORENE BY CYTOCHROME P-450 (The 6th Meeting for the Study of Toxic Effect)
• DEGRADATION OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE (The 5th Meeting for the Study of Toxic Effect)
• Efficacy of a 14-day course of oral ciprofloxacin therapy for acute uncomplicated pyelonephritis
• Nerve injury-related erectile dysfunction following nerve-sparing radical prostatectomy : A novel experimental dissection model
• Alteration of glial cell line-derived neurotrophic factor family receptor alpha-2 mRNA expression and its co-expression with neuronal nitric oxide synthase in pelvic ganglia following unilateral cavernous nerve injury
• Outcome analysis for conservative management of Peyronie's disease
• Erectile dysfunction following nerve-sparing radical retropubic prostatectomy and its treatment with sildenafil
• Erosion of a penile prosthesis due to an indwelling urethral catheter as a late complication
• The correlation between penile tumescence measured by the erectometer and penile rigidity by the RigiScan
• A Case of Chronic Infantile Neurological Cutaneous Articular (CINCA) Syndrome with Marked Growth Disturbance
• Fractal Dimension of Grain-boundary Fracture for Characterization of High-temperature Fracture in Heat-resistant Alloys
• Quantitative Evaluation of the Impact Fracture Surfaces of SS400 Steel by the Three-dimensional Geometrical Analysis
• Fractal Analysis of Fracture Surfaces in Materials Crept at High Temperatures or Fatigued by Repeated Bending
• Change in the Fracture Surface Pattern in the Fracture Process of SUS631 Stainless Steel Fatigued by Repeated Bending
• Characterization of Insulin-Dependent Diabetes Mellitus Induced by a New Variant (DK-27) of Encephalomyocarditis Virus in DBA/2 Mice
• TOXICOKINETICS:ITS SIGNIFICANCE AND PRACTICAL PROBLEMS
• Further Studies on the Persistence of Neonatal Androgen Imprinting on Sex-Specific Cytochrome P-450, Testosterone and Drug Oxidations
• Effects of Hypophysectomy and Growth Hormone Treatment on Sex-Specific Forms of Cytochrome P-450 in Relation to Drug and Steroid Metabolisms in Rat Liver Microsomes
• METABOLIC FATE OF FEPRAZONE
• EFFECTS OF α- AND β-ADRENERGIC BLOCKERS ON CHLORPROMAZINE-INDUCED ELEVATION OF PLASMA GLUCOSE AND CYCLIC AMP IN FED MICE
• EFFECT OF CHLORPROMAZINE ON INSULIN RELEASE IN MICE: COMPARISON BETWEEN IN VIVO AND IN VITRO
• AN UNUSUAL METABOLITE OF TESTOSTERONE BY CYTOCHROME P-450
• Anthralin, a Non-TPA Type Tumor Promoter, Synergistically Enhances Phorbol Ester-Caused Prostaglandin E2 Release from Primary Cultured Mouse Epidermal Cells
• Inhibitory Regulation of Serum Factor(s)-Caused Ornithine Decarboxylase Induction by the Protein Kinase C System in A431 Human Epidermoid Carcinoma Cells
• Mechanism of Thyroxine-induced Increase in Steroid Δ4-Reductase Actiyity in Male Rats
• Effect of Adrenalectomy on the Substrate Interaction with Cytochrome P-450 in the Hydroxylation of Steroid Hormones by Liver Microsomes
• PARTIAL AGONISTIC ACTION OF MORPHINE IN THE RAT VAS DEFERENS
• TOXICITY OF PLATINUM COMPLEXES WITH ANTITUMOR ACTIVITY (I)
• INHIBITION BY SKF 525-A OF 7-ETHOXYCOUMARIN O-DEETHYLATION IN MICROSOMAL AND THE RECONSTITUTED MONOOXYGENASE SYSTEMS FROM PCB-TREATED RAT LIVERS
• SA-06-2(013) Size Distribution of Creep Cracks and Fracture Mechanisms in High-Temperature Materials(Flaw Assessment at Elevated Temperature 1)
• PREVENTION OF CATECHOLAMINE RELEASE FROM ADRENAL CHROMAFFIN CELLS BY PHOSPHOLIPASE A2- AND LIPOXYGENASE-INHIBITORS
• Activation of Phorbol Ester Responsive Form of Protein Kinase CC in Association with Ca^ : Induced Differentiation of Primary Cultured Mouse Epidermal Cells
• Effect of Androgen and Estrogen on the Hydroxylation of Steroid Hormones by Rat Liver Microsomes
• Expression and Functional Characterization of a Rat Sulfotransferase (ST1A1)cDNA for Sulfations of Phenolic Substrates in COS-1 Cells
• Microstructures of Cutting Chips of SUS430 and SUS304 Steels, and NCF 750 and 6061-T6 Alloys
• THE APPARENT LOSS OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE
• Plasma cyclic AMP in the pethidine-dependent rat.
• Hepatic level of mRNA in relation to polymorphism and strain difference in expression of cytochrome P-450g.
• Effect of Systemic L-Arginine Administration on Hemodynamics and Nitric Oxide Release in Man.
• Dexamethasone Inhibits Nitric Oxide Synthase mRNA Induction by Interleukin-1.ALPHA. and Tumor Necrosis Factor-.ALPHA. in Vascular Smooth Muscle Cells.
• Nitric Oxide Synthase mRNA in Endothelial Cells: Synergistic Induction by Interferon-.GAMMA., Tumor Necrosis Factor-.ALPHA. and Lipopolysaccharide and Inhibition by Dexamethasone.
• Drug oxidation activities of horseradish peroxidase, myoglobin and cytochrome P-450cam reconstituted with synthetic hemes.
• Regulations of Male-Dominant P-450Md mRNA in Rat Liver by Hormonal Factors and Xenobiotics.
• Inhibition of teleocidin-caused epidermal ornithine decarboxylase induction by phospholipase A2-, cyclooxygenase- and lipoxygenase-inhibitors.
• Synergistic Stimulation of Prostaglandin E2 Release by Epidermal Growth Factor and a Tumor Promoter Anthralin from Primary Cultures of Mouse Epidermal Cells.
• Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced increase in vascular permeability in mouse skin by lipoxygenase inhibitors.
• Comparison of some biochemical properties of epidermis in tumor promotion-susceptible and -resistant strains of mice.
• Induction of cytochrome P-450c and P-450d by metyrapone in the primary culture of rat hepatocytes.
• Nitric Oxide in Vascular Remodeling.
• Beneficial Circulatory Effect of L-Arginine.
• Tension-induced release of endothelium-derived relaxing factor; Possible role in establishment of desensitization of norepinephrine-induced contraction in rat aorta.
• Fractal Analysis of Fracture Surfaces and Simulation of Fracture Process Using Fractal Dimension Maps in Stainless Steels Fatigued by Repeated Bending

もっと見る 閉じる

スポンサーリンク