Induction of cytochrome P-450c and P-450d by metyrapone in the primary culture of rat hepatocytes.
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概要
- 論文の詳細を見る
The effects of metyrapone on qualitative changes in cytochrome P-450-dependent drug metabolizing activities in primary cultures of rat hepatocytes were investigated. Metyrapone apparently increased benzo(a)pyrene hydroxylation and maintained both ethoxycoumarin-O-deethylation and propoxycoumarin-O-depropylation, whereas it had little effect on methoxycoumarin-0-demethylation. Furthermore, P-450d (high spin type of P-448) as well as P-450c (low spin type of P-448) were induced by metyrapone, while P-450b and P-450e were not. In conclusion, metyrapone act as a 3-methylcholanthrene-like inducer in the primary cultures of rat hepatocytes.
- 公益社団法人 日本薬理学会の論文
著者
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Kawanishi Toru
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present
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Hirota Kouichi
Department Of Neurology Akita Red Cross Hospital
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Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University
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MURAKOSHI Yoshie
Department of Pharmacy, College of Science and Technology, Nihon University
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TAKANAKA AKIRA
Department of Pharmaceutical Sciences, The Institute of Public Health
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Ohno Yasuo
Department Of Electric And Electronic Engineering The University Of Tokushima
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HIROTA Kouichi
Department of Pharmacology, National Institute of Hygienic Sciences
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KAWANISHI Toru
Department of Pharmacology, National Institute of Hygienic Sciences
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SUNOUCHI Momoko
Department of Pharmacology, National Institute of Hygienic Sciences
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Murakoshi Yoshie
Department of Pharmacology, Nihon University College of Pharmacy
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OHNO Yasuo
Department of Pharmacology, National Institute of Hygienic Sciences
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YAMAZOE Yasushi
Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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