Coagulation and Fibrinolysis Abnormalities the Acute Stage of Hypertensive Intracerebral Hemorrhage, with Special Reference to Fibrinopeptides A and Bβ15-42
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概要
- 論文の詳細を見る
Coagulation studies were performed in 11 patients in the acute stage of hypertensive intracerebral hemorrhage. The items tested include platelet count, prothrombin time, partial thromboplastin time, fibrinogen, antithrombin III, fibrin/fibrinogen degradation products, α_2 macroglobulin, α_2 plasmin inhibitor, fibrinopeptide A (FPA), and fibrinopeptide Bβ15-42 (FPBβ). Blood was collected from peripheral veins within 6 hours and again between the 7th and 14th days after the onset of symptoms. Disseminated intravascular coagulation (DIC) occurred in one patient, in whom the tests were repeated several times for 14 days. Fibrinopeptide levels were extremely high within 6 hours after the onset of symptoms and normalized between the 7th and 14th days. Fibrinopeptides were: especially high in the patient with DIC, which was caused by primary brain damage. Normal FPA levels were restored sooner than those of the other substances after administration of heparin and gabexate mesilate. It appears that damage to cerebral tissue occasionally brings about DIC and that FPA and FPBβ may be excellent indices for predicting coagulation and fibrinolytic imbalance and for managing DIC.
- 日本脳神経外科学会の論文
- 1986-07-15
著者
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KARASAWA Jun
Department of Neurosurgery, Osaka Neurological Institute
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Karasawa Jun
Department Of Neurosurgery Osaka Neurological Institute
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Karasawa Jun
Department Of Neurological Surgery Kitano Hospital
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OHNO Yasuo
Department of Electrical and Electronic Engineering, The University of Tokushima
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HINO Akihiko
Department of Neurosurgery, Saiseikai Shiga Hospital
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Hino Akihiko
Department Of Neurosurgery Kyoto Prefectural University Of Medicine
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Hino Akihiko
Department Of Neurosurgery Kyoto Second Red Cross Hospital
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HIRAKAWA Kimiyoshi
Department of Pulmonary Medicine, and University Medical School Teaching Hospital, Tokyo Medical and
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Hirakawa Kimiyoshi
Department Of Neurosurgery Kyoto Prefectural University Of Medicine
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TOHO Hajime
Department of Neurosurgery, Kyoto Prefectural University of Medicine
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Hirakawa Kimiyoshi
Deparmtent Of Neurosurgery:faculty Of Medicine University Of Tokyo
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Toho Hajime
Department Of Neurosurgery Kyoto Prefectural University Of Medicine
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Ohno Yasuo
Department Of Electrical And Electronic Engineering The University Of Tokushima
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Ohno Yasuo
Department Of Electric And Electronic Engineering The University Of Tokushima
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Ohno Yasuo
Department Of Research Special Reference Laboratories Inc.
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