CYTOGENIC ANALYSIS OF DOMINANT LETHAL EFFECTS OF MITOMYCIN C AND ETHYL METHANESULFONATE
スポンサーリンク
概要
- 論文の詳細を見る
To gain further insight into the mechanism of induction of dominant lethal mutations, the relationship between chromosome aberrations in bone marrow and in male germ cells after treatment with mitomycin C (MMC) and ethyl methanesulfonate (EMS) was examined. In addition, we obtained fertilized eggs from the oviducts of crossbred female mice in the same way as in the dominant lethal mutation test, and examined chromosome aberrations in male pronuclei. MMC 2.5 and 5.0 mg/kg, EMS 175 and 350 mg/kg were given subcutaneously to slc-ICR mice. It was concluded that MMC causes a decrease in the sperm count by killing germ cells, which in turn causes an increase in the number of unfertilized eggs and preimplantation egg loss. MMC seems also to cause invisible damages in the chromosomes of spermatocytes which lead to dominant lethality. EMS induced chromosome damage in the post-meiotic germ cells, and this damage, in turn, produced chromosome aberrations in the eggs, resulting in a high incidence of dominant lethality.
- 日本トキシコロジー学会の論文
- 1987-02-25
著者
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OHNO Yasuo
Department of Electrical and Electronic Engineering, The University of Tokushima
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Komatsu Setsuko
Department of Molecular Biology, National Institute of Agrobiological Resources
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Komatsu Setsuko
Department Of Pharmacology Meiji College Of Pharmacy
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Hashimoto Takao
Department of Internal Medicine (II), The Jikei University School of Medicine
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TAKEUCHI Kouichi
Department of Pharmacology, Meiji College of Pharmacy
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Komatsu Setsuko
Department Of Molecular Biology National Institute Of Agrobiological Resources
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OHNO Setsuko
Department of pharmacology, Meiji College of Pharmacy
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Ohno Yasuo
Department Of Electrical And Electronic Engineering The University Of Tokushima
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Ohno Setsuko
Department Of Pharmacology Meiji College Of Pharmacy
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Takeuchi Kouichi
Department Of Pharmacology Meiji College Of Pharmacy
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Takeuchi Kouichi
Department Of Clinical Pharmacology Meiji Pharmaceutical University
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Hashimoto Takao
Department Of Pharmacology Meiji College Of Pharmacy
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Hashimoto Takao
Department Of Internal Medicine (ii) The Jikei University School Of Medicine
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Komatsu Setsuko
Department Of Applied Biological Science Faculty Of Science And Technology Tokyo University Of Scien
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Ohno Yasuo
Department Of Electric And Electronic Engineering The University Of Tokushima
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Ohno Yasuo
Department Of Pharmacology Nat. Inst. Hyg. Sci
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