IN VITRO FERTILIZATION AND DEVELOPMENT OF OVA OBTAINED FROM FEMALE MICE TREATED WITH AMINOPTERIN AND MITOMYCIN C.
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概要
- 論文の詳細を見る
We examined the effects of mitomycin C and aminopterin on ovulation in vivo and, fertilization, subsequent cleavage and implantation in slc-ICR female mice using methods of fertilization and culture in vitro. Chemicals were injected into mice at the MI (meiosis I) stage or 3 hours before the MI stage in order to examine their toxicity. Mitomycin C did not affect ovulation, but decreased the rate of fertilization. A high dose of mitomycin C (4 mg/kg) inhibited fertilization and the development of ova to the 2-cell stage. Aminopterin affected neither ovulation nor fertilization. At either the MII (meiosis II) stage or 3 hours before the MII stage, high doses (4 and 2 mg/kg) of mitomycin C arrested cleavage and implantation. The cleavage was blocked frequently between the 3-4 cell stage and the 5-8 cell stage. Aminopterin affected neither cleavage nor implantation.
- 日本トキシコロジー学会の論文
- 1986-11-25
著者
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Komatsu Setsuko
Department of Molecular Biology, National Institute of Agrobiological Resources
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Komatsu Setsuko
Department Of Pharmacology Meiji College Of Pharmacy
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Hashimoto Takao
Department of Internal Medicine (II), The Jikei University School of Medicine
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TAKEUCHI Kouichi
Department of Pharmacology, Meiji College of Pharmacy
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Komatsu Setsuko
Department Of Molecular Biology National Institute Of Agrobiological Resources
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OHNO Setsuko
Department of pharmacology, Meiji College of Pharmacy
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Ohno Setsuko
Department Of Pharmacology Meiji College Of Pharmacy
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Takeuchi Kouichi
Department Of Pharmacology Meiji College Of Pharmacy
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Takeuchi Kouichi
Department Of Clinical Pharmacology Meiji Pharmaceutical University
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Hashimoto Takao
Department Of Pharmacology Meiji College Of Pharmacy
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Hashimoto Takao
Department Of Internal Medicine (ii) The Jikei University School Of Medicine
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Komatsu Setsuko
Department Of Applied Biological Science Faculty Of Science And Technology Tokyo University Of Scien
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