MUTAGENICITY TESTS OF THE ANTITHYROID AGENT THIAMAZOLE. : CYTOGENETIC STUDIES ON MALE MICE
スポンサーリンク
概要
- 論文の詳細を見る
The mutagenic potential of thiamazole, an antithyroid agent, was investigated by an in vivo cytogenetic test and was compared with those of mitomycin C and vincristin. These drugs were subcutaneously injected into slc-ICR male mice either as a single dose or as multiple doses for 5 successive days. Thiamazole (90 or 180 mg/kg) did not increase the number of micronuclei in bone marrow cells. This drug also did not induce chromosomal aberrations in spermatogonium, spermatocyte, or bone marrow cells. On the other hand, mitomycin C (3.0 mg/kg) increased the appearance of chromosomal aberrations and micronuclei. Vincristin (0.2 mg/kg) induced bone marrow cells with a so called large micronucleus (d≧D/4). These results suggest that thiamazole may not have significant effects on the genetic systems of mice.
- 日本トキシコロジー学会の論文
- 1987-02-25
著者
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Komatsu Setsuko
Department of Molecular Biology, National Institute of Agrobiological Resources
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Komatsu Setsuko
Department Of Pharmacology Meiji College Of Pharmacy
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Hashimoto Takao
Department of Internal Medicine (II), The Jikei University School of Medicine
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TAKEUCHI Kouichi
Department of Pharmacology, Meiji College of Pharmacy
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Komatsu Setsuko
Department Of Molecular Biology National Institute Of Agrobiological Resources
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OHNO Setsuko
Department of pharmacology, Meiji College of Pharmacy
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Ohno Setsuko
Department Of Pharmacology Meiji College Of Pharmacy
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Takeuchi Kouichi
Department Of Pharmacology Meiji College Of Pharmacy
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Takeuchi Kouichi
Department Of Clinical Pharmacology Meiji Pharmaceutical University
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Hashimoto Takao
Department Of Pharmacology Meiji College Of Pharmacy
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Hashimoto Takao
Department Of Internal Medicine (ii) The Jikei University School Of Medicine
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Komatsu Setsuko
Department Of Applied Biological Science Faculty Of Science And Technology Tokyo University Of Scien
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