Mechanism of the Re-buildup Rhenomenon in Moyamoya Disease : Analysis of Local Cerebral Hemodynamics with Intra-arterial Digital Subtraction Angiography

概要

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The authors investigated the mechanism of the re-buildup phenomenon on electroencephalogram in 14 patients of moyamoya disease with superficial temporal artery-middle cerebral artery anastomosis. Visualization of the lateral view of the common carotid angiography was performed with intra-arterial digital subtraction angiography (IA-DSA), using a 4/sec × 3 sec + 2/sec × 5 sec + 1/sec × 5 sec film sequence. The catheter tip was inserted into C5/6 level and 250 mgI/ml of iopamidol was used as the contrast agent; 6 ml in total was injected over 1.5 seconds. Circulation times of the common carotid artery (C_3 portion)-ascending parietal vein (ΔTTP_S) and common carotid artery-internal cerebral vein (ΔTTP_D) were measured before hyperventilation (HV), immediately after HV, and 3 minutes after HV during pre- and postoperative periods. ΔTTP_D in the preoperative period was prolonged by HV and was normalized at 3 minutes after HV but ΔTTP_S were prolonged immediately after and 3 minutes after HV. In the postoperative period, however, these values did not change significantly immediately after and 3 minutes after HV. These findings indicate that delayed cerebral blood flow response to HV is a pathogenetic factor of the re-buildup phenomenon in moyamoya disease.
日本脳神経外科学会の論文
1990-10-15