Changes in Local Cerebral Blood Flow,Glucose Utilization,and Mitochondrial Function Following Traumatic Brain Injury in Rats
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概要
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The pathophysiology of secondary brain damage following experimental traumatic brain injury was investigated by measuring local cerebral blood flow(ICBF),local cerebral glucose utilization(ICGU),and activity of succinate dehydrogenase(SDH),which is a mitochondrial enzyme of the tricarboxylic acid cycle,in the rat brain after moderate lateral fluid percussion injury.Measurements used autoradiography for ICBF and ICGU with [^<14>C]iodoantipyrine and [^<14>C]2-deoxyglucose,respectively.Regional SDH activity was determined using quantitative imaging of formazan produced from 2,3,5triphenyl tetrazolium chloride by SDH.ICBF decreased at 1 hour after injury and was significantly lower than the preinjury level in almost all regions of both hemispheres at 6 and 24 hours,and remained low at 2 weeks.ICGU increased 1 hour after injury but was significantly decreased at 6 and 24 hours,and at 2 weeks in most regions of both hemispheres.The ipsilateral hemisphere showed a significant decrease in the activity of SDH in the cortices,hippocampus,thalamus,and caudate/putamen,most conspicuously 72 hours after injury,whereas no significant decrease was observed in the contralateral hemisphere at any time.Necrosis in the injured cortex and reduction of the number of neurons in the ipsilateral hippocampus were observed 2 weeks after injury.The present study showed that a decrease in ICBF and mitochondrial dysfunction occur with glucose hypermetabolism around 1 hour after lateral fluid percussion injury,and that ICBF,ICGU,and mitochondrial function all deteriorate after 6 hours.This suggests that ICBF and cellular metabolism may change dynamically during the several hours following traumatic brain injury,and afterwards neuronal damage may result in an irreversible change in the areas with depressed glucose hypermetabolism in the early period after injury in combination with mitochondrial dysfunction.
- 日本脳神経外科学会の論文
- 2000-01-15
著者
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Ogawa Koji
Positron Medical Center Tokyo Metropolitan Institute Of Gerontology
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KUROIWA Toshihiko
Department of Neurosurgery, Osaka Medical College
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Oda K
Positron Medical Center Tokyo Metropolitan Institute Of Gerontology
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Oda Keiichi
放射線医学総合研究所分子イメージング研究センター 先端生体計測研究グループ
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Oda Keiichi
東京医科歯科大学 肝胆膵外科
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NARIAI Tadashi
Department of Neurosurgery, Tokyo Medical and Dental University
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Tanizaki Noaki
日本医科大学 第2内科
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Nariai T
Department Of Neurosurgery Tokyo Medical And Dental University
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Nariai Tadashi
東京医科歯科大学 脳神経外科
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Nozaki T
Tokyo Metropolitan Inst. Gerontology
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OHNO Kikuo
Department of Neurosurgery, Graduate School, Tokyo Medical and Dental University
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HIRAKAWA Kimiyoshi
Department of Pulmonary Medicine, and University Medical School Teaching Hospital, Tokyo Medical and
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Jiang Xiao
Department Of Physical Electronics Tokyo Institute Of Technology
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Jiang Xiao
Department Of Neurosurgery Tokyo Medical And Dental University
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Hirakawa Kimiyoshi
Department Of Neurosurgery Tokyo Medical And Dental University
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QLAN Liang
Department of Neurosurgery,Tokyo Medical and Dental University
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TOMINAGA Ben
Department of Neurosurgery,Tokyo Medical and Dental University
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Qlan Liang
Department Of Neurosurgery Tokyo Medical And Dental University
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Kuroiwa Toshihiko
Department Of Neuropathology Tokyo Medical And Dental University
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Kuroiwa Toshihiko
Department Of Neuropathology Graduate School Of Medicine Tokyo Medical And Dental University
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Hirakawa Kimiyoshi
Deparmtent Of Neurosurgery:faculty Of Medicine University Of Tokyo
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Ohno Kikuo
Department Of Neurosurgery Faculty Of Medicine Tokyo Medical:dental University
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Nariai Tadashi
Department Of Neurosurgery Tokyo Medical And Dental University
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Tominaga Ben
Department Of Neurosurgery Tokyo Medical And Dental University
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Nozaki Tadashi
Positron Medical Center Tokyo Metropolitan Institute Of Gerontology
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KUROIWA Toshihiko
Department of Neuropathology,Tokyo Medical and Dental University
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