k-Opioid Agonists Do Not Inhibit Adenylate Cyclase

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概要

• 論文の詳細を見る

• Morphine, levorphanol and D-Ala^2,Met enkephalin, but not bremazocine, pentazocine, U-50 488H and U-69 593,were found to inhibit adenylate cyclase activity dose-dependently in bullfrog brain membranes. The inhibition of the enzyme activity was abolished by naloxone. These results suggest that the signalling transduction of μ-and δ-agonists is partially mediated by the adenylate cyclase system coupled with opioid receptors, but that k-receptors may not be associated with adenylate cyclase.

• 公益社団法人日本薬学会の論文

著者

• MAKIMURA Mizue

  Department of Pharmacology, College of Pharmacy, Nihon University

• Makimura M

  Department Of Pharmacy College Of Science And Technology Nihon University

• Makimura Mizue

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present

• MURAKOSHI Yoshie

  Department of Pharmacy, College of Science and Technology, Nihon University

• Murakoshi Yoshie

  Department Of Pharmacy College Of Science And Technology Nihon University

• Murakoshi Yoshie

  Department of Pharmacology, Nihon University College of Pharmacy

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