Effects of Repeated Administration of a κ-Opioid Agonist on Phorbol Ester Binding to Membrane-Bound Protein Kinase C in Rat Brain
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概要
- 論文の詳細を見る
The dissociation constant (K_D) of [^3H] phorbol 12,13-dibutyrate (PDBu) binding to protein kinase C (PKC) in membranes of rat cortex and midbrain was significantly decreased with no change in the receptor density (B_<max>) following 7-d treatment with a κ-opioid agonist, U-50,488 (20mg/kg/d, i.p.). Neither the B_<max> nor K_D values in pons/medulla were altered by repreated U-50,488 treatment. These results suggest that repeated administration of a κ-opioid agonist increases the affinity for PDBu binding to the membrane-bound PKC in rat cortex and midbrain, but not in pons/medulla.
- 公益社団法人日本薬学会の論文
- 1996-02-15
著者
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NARITA Minoru
Department of Toxicology, School of Pharmacy, Hoshi University
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Narita M
Department Of Toxicology Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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MAKIMURA Mizue
Department of Pharmacology, College of Pharmacy, Nihon University
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Makimura Mizue
Department Of Pharmacology And Toxicology University Of Mississippi Medical Center
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Makimura Mizue
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present
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FENG Yangzheng
Department of Pediatrics, University of Mississippi Medical Center
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Narita Minoru
Department Of Emergency Medicine Tokyo Women's Medical University
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Feng Y
Univ. Mississippi Medical Center Ms Usa
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Feng Yangzheng
Department Of Pediatrics University Of Mississippi Medical Center
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HOSKINS Beth
Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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HO I.K.
Department of Pharmacology and Toxicology, University of Mississippi Medical Center
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Ho I.k.
Department Of Pharmacology And Toxicology University Of Mississippi Medical Center
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Hoskins Beth
Department Of Pharmacology And Toxicology University Of Mississippi Medical Center
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Narita Minoru
Department Of Anesthesiology Medical College Of Wisconsin
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