Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Generalizations of NMDA-receptor antagonists to the discriminative stimulus effects of κ-opioid receptor agonists in rats were examined. Phencyclidine, MK-801, and ketamine, non-competitive NMDA-receptor antagonists, generalized to the discriminative stimulus effects of U-50,488H, but not those of TRK-820, whereas (±)-3-(2-carbaxypiperazine-4-yl) propyl-1-phosphonic acid (CPP), a competitive NMDA-receptor antagonist, and ifenprodil, an NR1/NR2B NMDA-receptor antagonist, did not, suggesting that non-competitive NMDA-receptor antagonists possess U-50,488H-like discriminative stimulus effects in rats. Since U-50,488H and phencyclidine both induce aversive effects, our findings indicate that the cue of the discriminative stimulus effects of U-50,488H and non-competitive NMDA-receptor antagonists may be associated with their aversive effects.
- 社団法人 日本薬理学会の論文
- 2006-02-20
著者
-
Nagase H
Basic Research Laboratories Toray Industries Inc.
-
Nagase Hiroshi
Pharmaceutical Research Laboratories Toray Industries Inc.
-
SUZUKI Tsutomu
Department of Applied and Environmental Chemistry, Kitami Institute of Technology
-
Sawaguchi T
Department Of Emergency Medicine Tokyo Women's Medical University
-
NARITA Minoru
Department of Toxicology, School of Pharmacy, Hoshi University
-
MORI Tomohisa
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences
-
NOMURA Mutsuko
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences
-
YOSHIZAWA Kazumi
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences
-
NAGASE Hiroshi
Basic Research Laboratories, Toray Industries, Inc.
-
SAWAGUCHI Toshiko
Department of Legal Medicine, Tokyo Women's Medical University
-
Sawaguchi Toshiko
Department Of Anatomy Keio University
-
Nomura Mutsuko
Department Of Toxicology Hoshi University School Of Pharmacy And Pharmaceutical Sciences
-
Namiki Mizuho
Dep. Of Emergency Medicine Tokyo Women's Medical Univ. Jpn
-
Namiki Mizuho
Department Of Emergency Medicine Tokyo Women's Medical University
-
Mori Tomohisa
Department Of Legal Medicine Tokyo Women's Medical University
-
Narita Minoru
Department Of Emergency Medicine Tokyo Women's Medical University
-
Yoshizawa Kazumi
Department Of Toxicology Hoshi University School Of Pharmacy And Pharmaceutical Sciences
-
Narita Minoru
Department Of Anesthesiology Medical College Of Wisconsin
-
Nagase Hiroshi
Basic Research Laboratories Toray Industries Inc.
-
Nomura Mutsuko
Department Of Emergency Medicine Tokyo Women's Medical University
-
Suzuki Tsutomu
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
関連論文
- Nickel-catalyzed carbonization of wood for coproduction of functional carbon and fluid fuels II : improved fuel quality of oil fraction and increased heating value of gas fraction
- Nickel-catalyzed carbonization of wood for coproduction of functional carbon and fluid fuels I : production of crystallized mesoporous carbon
- Preparation of Crystallized and Mesoporous Carbon by Nickel-catalyzed Carbonization of Wood
- Electromagnetic Shielding Capacity of Wood Char Loaded with Nickel
- Recent Advances in the Search for the μ-Opioidergic System : Preface
- Gastric Tube Interposition for Corrosive Esophagitis Associated with Pyloric Stenosis
- Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models
- S2-3 Opiate Psychotoxicity : role of NMDA recepter subunits and protein kinase C(Proceedings of the 27th Annual Meeting)
- 1SE1020 Genetic code extension and establishment by aminoacyl-tRNA synthetase and tRNA modification enzymes(1SE Recent Advances in Structural Analyses of Funcitonal Mechanisms Based on Dynamics of Biological Reactions,The 48th Annual Meeting of the Biophy
- BEHAVIORAL CHANGES IN MORPHINE-TOLERANT MICE
- STUDIES ON DRUG DEPENDENCE (REPT. 72) BRAIN MORPHINE LEVELS OF DEPENDENT MICE BY DAF (DRUG-ADMIXED FOOD) METHOD
- STUDIES ON DRUG DEPENDENCE (REPT. 52) INDUCTION OF MORPHINE DEPENDENT MICE BY DAF (DRUG-ADMIXED FOOD) METHOD
- Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats
- Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective δ-Opioid Agonist, in Behavioral Models in Rodents
- Lack of μ-Opioid Receptor-Mediated G-Protein Activation in the Spinal Cord of Mice Lacking Exon 1 or Exons 2 and 3 of the MOR-1 Gene
- TRK-820, a Selective к-Opioid Agonist, Produces Potent Antinociception in Cynomolgus Monkeys
- INTERACTION BETWEEN MU AND KAPPA RECEPTORS IN PHARMACOLOGICAL EFFECTS OF TOLERANCE TO AND DEPENDENCE ON SEVERAL OPIOIDS
- High Electroconductivity of Wood Char Obtained by Iron-catalyzed Carbonization
- The First Example of the Stereoselective Synthesis of 7β-Carbamoyl-4,5α-epoxymorphinan via a Novel and Reactive γ-Lactone
- Syntheses of Potential Metabolites of a Potent к-Opioid Receptor Agonist, TRK-820
- Syntheses of 10-Oxo, 10α-Hydroxy, and 10β-Hydroxy Derivatives of a Potent к-Opioid Receptor Agonist, TRK-820
- Rational Drug Design and Synthesis of a Highly Selective Nonpeptide δ-Opioid Agonist, (4aS^*, 12aR^*)-4a-(3-Hydroxyphenyl)-2-methyl-1,2,3,4,4a, 5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67)
- DISCOVERY OF A STRUCTURALLY NOVEL OPIOID K-AGONIST DERIVED FROM 4,5-EPOXYMORPHINAN
- NOR-BINALTORPHIMINE (NOR-BNI) : POTENT AND SELECTIVE KAPPAOPIOID RECEPTOR ANTAGONIST WITH LONG-LASTING ACTIVITY IN VIVO
- Antinociceptive Effect of the Combination of Pentazocine With Morphine in the Tail-Immersion and Scald-Pain Tests in Rats
- Recent Advances in the Search for the μ-Opioidergic System : Endomorphin-induced Motivational Effect : Differential Mechanism of Endomorphin-1 and Endomorphin-2
- COMPARISON OF PHARMACOLOGICAL PROPERTIES BETWEEN PENTAZOCINE AND HOMOBENZOMORPHAN DERIVATIVES
- Structural Confirmation of 15-Norlubiminol and 15-Norepilubiminol, Isolated from Solanum aethiopicum, by Chemical Conversion from Lubimin and Epilubimin, and their Antifungal Activity(Organic Chemistry)
- STUDIES ON THE MECHANISM OF INTERACTION BETWEEN METHAMPHETAMINE AND QUININE IN RATS
- Thoracic Esophagectomy Combined with Pylorus-Preserving Pancreatoduodenectomy in a One-Stage Procedure : Report of a Case
- A Novel Screening System for Self-mRNA Targeting Proteins
- NARCOTIC PHYSICAL DEPENDENCE AND URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
- Complicated Interaction Between Psychostimulants and Morphine in Expression of Phenotype of Behavior in the Dopaminergic System of BALB/c Mice
- Underlying Mechanism of Combined Effect of Methamphetamine and Morphine on Lethality in Mice and Therapeutic Potential of Cooling
- Implication of the Descending Dynorphinergic Neuron Projecting to the Spinal Cord in the (+)-Matrine-and (+)-Allomatrine-Induced Antinociceptive Effects(Medicinal Chemistry)
- Effects of Dopamine- and Serotonin-Related Compounds on Methamphetamine-Induced Self-Injurious Behavior in Mice
- Combined Effects of Psychostimulants and Morphine on Locomotor Activity in Mice
- Recent Advances in the Search for the μ-Opioidergic System : Differential Mechanism of G-Protein Activation Induced Endogenous μ-Opioid Peptides, Endomorphin and β-Endomorphin
- Modulation of the Discriminative Stimulus Effects of Cocaine and Methamphetamine by the Histaminergic System
- Evaluation of the Histamine H_1-Antagonist-Induced Place Preference in Rats
- Interaction between Discriminative Stimulus Effects of Cocaine and Morphine
- 1P014 Snapshots of tRNA sulfuration via an adenylated intermediate(1. Protein structure and dynamics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- P-532 Structure-Antitussive Activity Relationships of Naltrindole Derivatives : Discovery of Novel and Potent Antitussive Agents
- Design and Simulation of 4Q-Multiplier Using Linear and Saturation Regions of MOSFET Complementally(Special Section on Papers Selected from ITC-CSCC 2001)
- Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease
- Modification Defect at Anticodon Wobble Nucleotide of Mitochondrial tRNAs^(UUR) with Pathogenic Mutations of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes
- Production of Crystallized Carbon for Electromagnetic Shielding from Lignocresol by Nickel-Catalyzed Carbonization : Influence of Calcium Co-loading (I)
- Nickel-Catalyzed Carbonization of Lignocresol to Produce Crystallized Carbon Usable for Electromagnetic Shielding
- Immunohistochemical study of secretory granule membrane : 1. granules of intercalated duct and cell membrane specific antibodies
- Effect of Diabetes on the Morphine-Induced Inhibition of Gastrointestinal Tranist
- Evidence for the Existence of the β-Endorphin-Sensitive "ε-Opioid Receptor" in the Brain: The Mechanisms of ε-Mediated Antinociception
- Sex Differences in the Induction of Physical Dependence on Pentobarbital in the Rat
- A NEW APPROACH FOR ASSESSMENT OF NARCOTIC PHYSICAL DEPENDENCE USING URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
- Effect of Heat Treatment on Ion Conductivity of Hydrated ZrO2 Thin Films Prepared by Reactive Sputtering Using H2O Gas
- On the Dynamical Tendency of Intuitively Designed Shapes
- EFFECTS OF NIFEDIPINE ON PHYSICAL DEPENDENCE ON BARBITAL OR DIAZEPAM IN RATS
- Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice
- ABNORMAL REACTION OF 4,5-EPOXYDIHYDROMOROHINONES AND ITS APPLICATION TO THE SYNTHESES OF OPIOID RECEPTOR ANTAGONISTS
- S9-4 Molecular mechanism of changes in the morphine-induced rewarding effect under chronic pain-like state : Suppression of dopaminergic transmission in the brain(SYMPOSIUM 9: MOLECULAR MECHANISMS OF DRUG DEPENDENCE)(Proceedings of the 31st Annual Meeting
- Chronic treatment with diphenylarsinic acid (DPAA) affects central nerves system(Proceedings of the 32nd Annual Meeting)
- Effects of Repeated Administration of a κ-Opioid Agonist on Phorbol Ester Binding to Membrane-Bound Protein Kinase C in Rat Brain
- Peritoneovenous Shunting for Intractable Chylous Ascites Complicated with Lymphangioleiomyomatosis
- Thymic Adenocarcinoma with Sarcomatoid Features Characterized by Intracaval Tumor Growth : Report of a Case
- EATING BEHAVIOR REVEALS RATS PREFERENCE FOR MORPHINE
- Effects of Substrate Cooling during Sputter Deposition of Hydrogen-Containing Ta2O5 Thin Films in H2O Atmosphere on their Ion Conductivity
- Effects of κ-Agonist on the Antinociception and Locomotor Enhancing Action Induced by Morphine in Mice
- EFFECTS OF QUINIDINE AND CIMETIDINE ON METHAMPHETA MINE STEREOTYPY IN RATS
- Contribution of Glutamate Receptors to Benzodiazepine Withdrawal Signs
- High Catalytic Activity of Ion-Exchanged Nickel on Carboxymethylated Wood Char in Methanation of Carbon Monoxide
- PHYSICAL DEPENDENCE ON MORPHINE, PHENOBARBITAL AND DIAZEPAM IN RATS BY DRUG-ADMIXED FOOD INGESTION
- CROSS-CEPENDENCE BETWEEN PHENOBARBITAL AND ALCOHOL IN RATS
- PREFERENCE FOR MORPHINE AND DRUG-SEEKING BEHAVIOR IN MORPHINE DEPENDENT RATS
- EATING PATTERN OF MORPHINE DEPENDENT RATS
- ORAL SELF-ADMINISTRATION OF MORPHINE IN RATS
- SYNTHESES OF DELTA OPIOID ANTAGONISTS AND THEIR STRUCTURE ACTIVITY RELATIONSHIPS
- P-II-A-7 Caffeine's (CAF) Effect on Methamphetamine (MAP), Cocaine (CAN), Morphine(MRP) and Pentobarbital(PTB)-induced Conditioned Place Preference in Mice. 日本動物心理学会第51回大会発表要旨
- P-II-5 The Effect of Methamphetamine and Caffeine on Place Preference Conditioning(日本動物心理学会第50回大会発表)
- Characteristics of suicide among children and adolescents in Budapest
- Refractory Recurrent Thymoma Successfully Treated with Long-acting Somatostatin Analogue and Prednisolone
- Hydrogasification of wood for high heating-value gas production X : Effect of pretreatment of Japanese oak bark by HNO_3 oxidation on subsequent iron-catalyzed hydrogasification
- Effects of Neonatal Injections of Estrogen in Combination with Vitamin A on the Vaginal Epithelium of Adult Mice
- Discriminative Stimulus Effects of Hallucinogenic Drugs: a Possible Relation to Reinforcing and Aversive Effects
- Involvement of the Arachidonic Acid Cascade in the Hypersusceptibility to Pentylenetetrazole-Induced Seizure during Diazepam Withdrawal
- Discriminative Stimulus Effects of Hallucinogenic Drugs : a Possible Relation to Reinforcing and Aversive Effects
- Potential Anxiolytic and Antidepressant-Like Activities of SNC80, a Selective .DELTA.-Opioid Agonist, in Behavioral Models in Rodents
- Malignant Pleurisy Associated with Primary Lung Cancer Well Controlled by Pleurodesis Using Distilled Water
- Induction of physical dependence on codeine in the rat by drug-admixed food ingestion.
- The Role of Mu- and Kappa-Opioid Receptors in Cocaine-Induced Conditioned Place Preference.
- Induction of physical dependence on morphine in mice by the drug-admixed food method.
- Genetic differences in the development of physical dependence on pentobarbital in four inbred strains of rats.
- Blockade of .DELTA.-Opioid Receptors Prevents Morphine-Induced Place Preference in Mice.
- Cross-physical dependence of several drugs in methaqualone-dependent rats.
- Genetic differences in preferences for morphine and codeine in Lewis and Fischer 344 inbred rat strains.
- Involvement of Serotonin Receptor Mechanisms in the Discriminative Stimulus Effects of Ketamine in Rats
- Establishment of Opioid-Induced Rewarding Effects Under Oxaliplatin- and Paclitaxel-Induced Neuropathy in Rats