Effects of Dopamine- and Serotonin-Related Compounds on Methamphetamine-Induced Self-Injurious Behavior in Mice
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概要
- 論文の詳細を見る
Methamphetamine induces hyperlocomotion, and high doses of methamphetamine induce self-injurious behavior (SIB) in rodents. It is well known that the monoaminergic system is involved in methamphetamine-induced behavior. However, the effects of dopamine- and serotonin (5-HT)-related compounds on high-dose methamphetamine-induced behavior have not been sufficiently clarified. Therefore, the present study was designed to investigate the effects of dopamine receptor antagonists and indirect 5-HT receptor agonists on high-dose methamphetamine-induced behavior in mice. Methamphetamine (20 mg/kg) initially increased locomotor activity. As the dosage increased, continuous SIB accompanied by a reduction in locomotor activity was observed. The hyperlocomotion and SIB induced by 20 mg/kg of methamphetamine was abolished by high doses of SCH23390 and haloperidol, indicating that the hyperlocomotion and SIB induced by high doses of methamphetamine are mediated by the activation of D1- and D2-receptors. Furthermore, haloperidol (0.1 mg/kg) potently increased locomotor activity in combination with 20 mg/kg methamphetamine. These results suggest that excess dopaminergic activation, especially activation of dopamine D2-receptors, may be involved in the decrease in locomotor activity induced by a high dose of methamphetamine. On the other hand, indirect 5-HT receptor agonists attenuated methamphetamine-induced SIB, suggesting that the stimulation of 5-HT receptors plays an important role in high-dose methamphetamine-induced SIB in mice.
- 社団法人 日本薬理学会の論文
- 2004-12-01
著者
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Sawaguchi T
Department Of Emergency Medicine Tokyo Women's Medical University
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Ito Shinobu
Vitamin C60 Bioresearch Corporation
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Ito Shinobu
Department Of Legal Medicine Tokyo Women's Medical University
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MORI Tomohisa
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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SAWAGUCHI Toshiko
Department of Legal Medicine, Tokyo Women's Medical University
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Suzuki Tsutomu
Department Of Emergency Medicine Tokyo Women's Medical University
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Sawaguchi Toshiko
Department Of Anatomy Keio University
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Kita Taizo
Section Of Addictive Drugs Research Division Of Drug Dependence National Institute Of Mental Health
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Mori Tomohisa
Department Of Legal Medicine Tokyo Women's Medical University
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