The Role of Mu- and Kappa-Opioid Receptors in Cocaine-Induced Conditioned Place Preference.
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概要
- 論文の詳細を見る
Effects of buprenorphine, U-50, 488H, naltrexone and lithium chloride on cocaine conditioned place preference were examined. Buprenorphine, a mixed opioid agonist-antagonist, blocked the cocaine-induced place preference. Furthermore, the kappa-receptor agonist U-50, 488H and the mu-receptor antagonist naltrexone both antagonized the cocaine preference. U-50, 488H or naltrexone alone induced a place aversion in a dose-dependent manner. However, the cocaine-induced conditioned place preference was not blocked by lithium chloride, although the latter induced a conditioned place aversion, indicating that the antagonism of cocaine-induced place preference by U-50, 488H or naltrexone does not result from a functional antagonism. These results suggest that mu- and kappa-opioid receptors may be involved in cocaine-induced conditioned place preference.
- 公益社団法人 日本薬理学会の論文
著者
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Misawa Miwa
Department Of Applied Pharmacology Hoshi University
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Nagase Hiroshi
Basic Research Laboratories Toray Industries Inc.
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Suzuki Tsutomu
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
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Masukawa Yoshikazu
Department of Applied Pharmacology, School of Pharmacy, Hoshi University
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Shiozaki Yoshinao
Department of Applied Pharmacology, School of Pharmacy, Hoshi University
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