Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo
スポンサーリンク
概要
- 論文の詳細を見る
To determine an in vivo venodilatation of nasal mucosa, which is thought to be one of the causes of nasal obstruction in allergic rhinitis, venous diameters of nasal septa were directly measured in anesthetized rats. An application of antigen to nasal mucosa of sensitized rats caused an increase in diameters of mucosal veins, that is, venodilatation : the maximal response (about 20% increase in diameters) was observed at 55 min after antigen challenge. The antigen-induced increase in venous diameter of nasal mucosa was significantly inhibited by pretreatment with a cysteinyl leukotrienes (CysLTs) receptor antagonist, SR2640, and a nitric oxide (NO) synthase inhibitor, N^G-monomethyl-L-arginine, indicating that CysLTs and NO might be involved in the venodilatation of nasal mucosa induced by antigen challenge. Blocking the action of CysLTs and NO might be therefore useful for the therapy of nasal obstruction in allergic rhinitis.
- 日本平滑筋学会の論文
著者
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CHIBA Yoshihiko
Department of Pharmacology, School of Pharmacy, Hoshi University
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MISAWA Miwa
Department of Pharmacology, School of Pharmacy, Hoshi University
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SAKAI Hiroyasu
Department of Internal Medicine, Gifu University Graduate School of Medicine
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千葉 喜彦
山口大学理学部時間生物学研究室
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Chiba Yoshihiko
Dep. Of Pharmacology School Of Pharmacy Hoshi Univ.
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OSHITA Michiko
Department of Pharmacology, School of Pharmacy, Hoshi University
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Chiba Yoshihiko
Department Of Pharmacology School Of Pharmacy Hoshi University
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Misawa Miwa
Department Of Pharmacology School Of Pharmacy Hoshi University
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Misawa M
Hoshi Univ. Tokyo Jpn
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Misawa Miwa
Department Of Applied Pharmacology Hoshi University
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Oshita Michiko
Department Of Pharmacology School Of Pharmacy Hoshi University
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Sakai Hiroyasu
Department Of Pharmacology School Of Pharmacy Hoshi University
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Sakai H
Department Of Pharmaceutical Physiology Graduate School Of Medicine And Pharmaceutical Sciences Univ
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Sugitani Hideki
Department Of Clinical Chemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Chiba Yoshihiko
Department Of Biology School Of Pharmacy Hoshi University
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