Y-27632 augments the isoflurane-induced relaxation of bronchial smooth muscle in rats

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概要

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• Recent studies revealed an involvement of RhoA/Rho-kinase signaling in the agonist-induced Ca2+ sensitization of bronchial smooth muscle contraction, and the pathway has now been proposed as a new target for the treatment of airway obstructive diseases, such as asthma. On the other hand, volatile anesthetics such as isoflurane are traditionally used to treat status asthmaticus. In the present study, the effect of inhibition of Rho-kinase on the isoflurane-induced relaxation of bronchial smooth muscle was investigated. Smooth muscle strips of intrapulmonary bronchi obtained from Wistar rats were used. Application of isoflurane (0.5-4.0%, generated by a calibrated vaporizer) to the acetylcholine (30 μM)-precontracted rat bronchial smooth muscles caused a concentration-dependent relaxation. Interestingly, the isoflurane-induced relaxation was significantly augmented by the pretreatment with subthreshold concentration of Y-27632, a Rho-kinase inhibitor. Thus, the combined use of Y-27632 and isoflurane might be useful for treatment of severe airway blockade, such as status asthmaticus.

著者

• SAKAI Hiroyasu

  Department of Internal Medicine, Gifu University Graduate School of Medicine

• Misawa Miwa

  Department Of Applied Pharmacology Hoshi University

• Morita Kiyoshi

  Department Of Anesthesiology And Resuscitology Okayama University Graduate School Of Medicine And De

• Kohjitani Atsushi

  Department Of Anesthesiology Kobe University School Of Medicine

• Chiba Yoshihiko

  Department Of Biology School Of Pharmacy Hoshi University

• Hanazaki Motohiko

  Department Of Anesthesiology And Intensive Care Medicine Kawasaki Medical School

• YOKOYAMA MASATAKA

  Department of Anatomy, Jikei University School of Medicine

• Hanazaki Motohiko

  Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

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