A new bronchial asthma model using calcium ionophore A23187 in guinea pigs.
スポンサーリンク
概要
- 論文の詳細を見る
We attempted to develop a non immunologically induced asthma model using the calcium ionophore A23187. Inhalation of A23187 (0.001-0.005%) for 5 min in male Hartley guinea pigs caused a marked bronchoconstriction in a dosedependent manner with negligible effect on systemic blood pressure. The A231 87induced bronchoconstriction was strongly inhibited by chlorpheniramine and FPL55712. These results indicate that an asthma-like bronchoconstriction was induced by inhalation of A23187 in guinea pigs, and the main chemical mediators involved in this response would be histamine and peptidoleukotrienes.
- 公益社団法人 日本薬理学会の論文
著者
-
Misawa Miwa
Department Of Applied Pharmacology Hoshi University
-
Takenouchi Kiyoteru
Department Of Applied Pharmacology School Of Pharmacy Hoshi University:research Institute Of Nippon
-
KAWAMURA Toshihiko
Department of Applied Pharmacology, School of Pharmacy, Hoshi University
関連論文
- Upregulation of interleukin-13 receptor chains in bronchial smooth muscle tissues of mouse experimental asthma
- Augmentation of Endothelin-1-Induced Phosphorylation of CPI-17 and Myosin Light Chain in Bronchial Smooth Muscle from Airway Hyperresponsive Rats(Pharmacology)
- INTERACTION BETWEEN MU AND KAPPA RECEPTORS IN PHARMACOLOGICAL EFFECTS OF TOLERANCE TO AND DEPENDENCE ON SEVERAL OPIOIDS
- SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice
- Mechanism of Inhibitory Effect of Prednisolone on RhoA Upregulation in Human Bronchial Smooth Muscle Cells
- Possible Involvements of Nuclear Factor-κB and Activator Protein-1 in the Tumor Necrosis Factor-α–Induced Upregulation of Matrix Metalloproteinase-12 in Human Alveolar Epithelial A549 Cell Line
- Tumor Necrosis Factor-α (TNF-α) Induces Upregulation of RhoA via NF-κB Activation in Cultured Human Bronchial Smooth Muscle Cells
- Functional importance of the cytoskeletal protein in acetylcholine-induced contraction of rat bronchial smooth muscle
- Glucocorticoids Ameliorate Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness by Inhibiting Upregulation of RhoA in Rats
- Increased expression of Gαq protein in bronchial smooth muscle of mice with allergic bronchial asthma
- Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine
- Involvements of cysteinyl leukotrienes and nitric oxide in antigen-induced venodilatation of nasal mucosa in sensitized rats in vivo
- Increase in the Expression of Matrix Metalloproteinase-12 in the Airways of Rats with Allergic Bronchial Asthma(Pharmacology)
- Effects of Repeated Antigen Exposure on Endothelin-1-Induced Bronchial Smooth Muscle Contraction and Activation of RhoA in Sensitized Rats
- Involvement of M_3 Muscarinic Receptors in ACh-Induced Increase in Membrane-Associated RhoA of Rat Bronchial Smooth Muscle(Pharmacology)
- Acetylcholine-Induced Translocation of RhoA in Freshly Isolated Single Smooth Muscle Cells of Rat Bronchi
- TNF-α augments the expression of RhoA in the rat bronchus
- Upregulation of rhoA mRNA in Bronchial Smooth Muscle of Antigen-induced Airway Hyperresponsive Rats
- Augmented PDBu-mediated contraction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness
- Involvement of multiple PKC isoforms in phorbol 12,13-dibutyrate-induced contraction during high K^+ depolarization in bronchial smooth muscle of mice
- A NEW SCREENING METHOD FOR EVALUATING ANTITUSSIVES IN CONSCIOUS GUINEA PIGS
- HISTAMINE RECEPTORS IN THE BRONCHIAL MUSCULATURE AND VASCULATURE OF THE DOG
- DRUG EFFECTS ON ELECTRICAL ACTIVITIES OF THE CANINE TRACHEAL CILIATED CELLS
- DIRECT EFFECTS OF EXPECTORANTS ON THE TRACHEOBRONCHIAL SYSTEM IN VIVO
- EFFECTS OF SOME DRUGS ON THE IMMUNE RESPONSE IN THE RESPIRATORY TRACT
- Evaluation of the Histamine H_1-Antagonist-Induced Place Preference in Rats
- Interaction between Discriminative Stimulus Effects of Cocaine and Morphine
- The Effect of Platelet-Activating Factor on Histamine Release from Guinea Pig Peritoneal Mast Cells
- Y-27632 augments the isoflurane-induced relaxation of bronchial smooth muscle in rats
- EFFECTS OF NIFEDIPINE ON PHYSICAL DEPENDENCE ON BARBITAL OR DIAZEPAM IN RATS
- The role of RhoA-mediated Ca^ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness
- Effects of κ-Agonist on the Antinociception and Locomotor Enhancing Action Induced by Morphine in Mice
- Identification and Characterization of Rat RhoA Gene Promoter
- Effects of Antiallergic Drugs on Bronchial and Cutaneous Anaphylaxes in Lewis Rats
- EFFECTS OF EXPECTORANTS ON THE CANINE TRACHEAL CILIATED CELLS
- EFFECTS OF β-ADRENOCEPTOR STIMULANTS ON THE CANINE TRACHEAL CILIATED CELLS
- EFFECTS OF QUINIDINE AND CIMETIDINE ON METHAMPHETA MINE STEREOTYPY IN RATS
- CONTINUOUS DETERMINATION OF TRACHEOBRONCHIAL SECRETORY ACTIVITY IN DOGS
- Abnormal Modulation of Cholinergic Neurotransmission by Endogenous Nitric Oxide in the Bronchus of Rats with Hyperresponsiveness Induced by Allergen Challenge
- Amyloid β Peptide Specifically Promotes Phosphorylation and Nuclear Translocation of the Extracellular Signal-Regulated Kinase in Cultured Rat Cortical Astrocytes
- The Induction of Long-Term Potentiation at Amygdalo-Hippocampal Synapses in Vivo(Pharmacology)
- Possible Involvements of Nuclear Factor-κB and Activator Protein-1 in the Tumor Necrosis Factor-α-Induced Upregulation of Matrix Metalloproteinase-12 in Human Alveolar Epithelial A549 Cell Line
- RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma
- Upregulation of geranylgeranyltransferase I in bronchial smooth muscle of mouse experimental asthma: its inhibition by lovastatin
- Activation of signal transducer and activator of transcription factor 1 by interleukins-13 and -4 in cultured human bronchial smooth muscle cells
- Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice
- EFFECTS OF 8-(2-FLUOROETHYL)-3α-HYDROXY-lαH, 5αH-TROPANIUMBROMIDE BENZILATE (Ba598Br) ON ALLERGY AND DRUG-INDUCED ASTHMAS
- ANALYSIS OF EFFERENT DISCHARGES OF THE PHRENIC NERVE DURING THE COUGH REFLEX
- PERIPHERAL EFFECTS OF MORPHINE AND CODEINE ON THE COUGH REFLEX
- EXPECTORANT EFFECT OF BROMHEXINE DERIVATIVES
- HISTOLOGICAL AND HISTOCHEMICAL ANALYSIS OF EXPECTORANT EFFECT
- A ROLE OF LYSOSOMAL ENZYMES IN THE MECHANISM OF MUCOLYTIC ACTION OF BROMHEXINE
- BEHAVIOR OF MUCUS GLYCOPROTEINS OF TRACHEAL SECRETORY CELLS FOLLOWING L-CYSTEINE METHYL ESTER TREATMENT
- EFFECT OF PILOCARPINE ON BEHAVIOR OF MUCUS GLYCOPROTEINS OF CANINE TRACHEAL SECRETORY CELLS
- P-II-5 The Effect of Methamphetamine and Caffeine on Place Preference Conditioning(日本動物心理学会第50回大会発表)
- Different effects of smoke from heavy and light cigarettes on the induction of bronchial smooth muscle hyperresponsiveness in rats
- Acetylcholine-Induced Smooth Muscle Contraction of Intrapulmonary Small Bronchi Is Augmented in Antigen-Induced Airway Hyperresponsive Rats
- Amyloid β protein enhances the clearance of extracellular _L-glutamate by cultured rat cortical astrocytes
- Acetylcholine-Induced Translocation of RhoA in Freshly Isolated Single Smooth Muscle Cells of Rat Bronchi
- Phosphorylation of Signal Transducer and Activator of Transcription 6 (STAT6) and STAT1, but Not STAT3, Induced by Antigen Inhalation in Bronchial Smooth Muscles of Sensitized Mice
- MicroRNAs and Their Therapeutic Potential for Human Diseases : MiR-133a and Bronchial Smooth Muscle Hyperresponsiveness in Asthma
- SKI-II, an Inhibitor of Sphingosine Kinase, Ameliorates Antigen-Induced Bronchial Smooth Muscle Hyperresponsiveness, but Not Airway Inflammation, in Mice
- RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma
- Identification of PKC isoforms expressed in human bronchial smooth muscle cell
- Inhibitory Reflex during Bronchoconstrictions Induced by Histamine and Ascaris Suum Antigen.
- The effect of trans-4-guanidinomethylcyclohexanecarboxylic acid p-tert-butylphenyl ester hydrochloride (NCO-650) on Ascaris suum antigen-induced bronchoconstriction in dogs.
- Strain difference in an allergic asthma model in rats.
- Induction of RhoA gene expression by interleukin-4 in cultured human bronchial smooth muscle cells
- Thermal decomposition of graphite fluoride. III. Thermal decomposition of (CF)n in oxygen atmosphere.
- Analysis of the vagal reflex tracheal constriction in the dog.
- A new bronchial asthma model using calcium ionophore A23187 in guinea pigs.
- Antitussive effect of RU-20201 - Central and peripheral actions.
- The Role of Mu- and Kappa-Opioid Receptors in Cocaine-Induced Conditioned Place Preference.
- The role of vagal reflex in mechanism of secretagogic action of bromhexine.
- Involvement of inhibitory innervation in reflex tracheal dilatation induced by lung inflation.
- Platelet-activating factor(PAF)-induced rhinitis and involvement of PAF in allergic rhinitis in guinea pigs.
- Effects of bromhexine on the secretions of saliva and tears.
- The effect of platelet-activating factor on histamine release from rat peritoneal mast cells.
- Blockade of .DELTA.-Opioid Receptors Prevents Morphine-Induced Place Preference in Mice.
- Cross-physical dependence of several drugs in methaqualone-dependent rats.
- Inhibitory modulation on the reflex tracheal constriction induced by afferent vagal stimulation.
- Genetic differences in preferences for morphine and codeine in Lewis and Fischer 344 inbred rat strains.