NARCOTIC PHYSICAL DEPENDENCE AND URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between urinary excretion of sex-dependent low molecular weight proteins (LMWP) in male rats and narcotic dependence is described in this study. Rats were intermittently infused with narcotics at one hour intervals through an implanted intravenous cannula. Development of physical dependence on morphine, pethidine, and pentazocine was detected by withdrawal signs including body weight loss and abnormal behaviors after naloxone challenge. In these animals, a significant decrease in urinary LMWP excretion was found following the second day of each drug treatment without significant changes in albumin excretion, and this decrease was observed continuously throughout the experiment. The markedly decreased level of LMWP recovered to the control level within 7 d after withdrawal of the drugs. These results suggest that the decrease in urinary excretion of sex-dependent LMWP in male rats is a phenomenon closely related to narcotic dependence.
- 公益社団法人日本薬学会の論文
著者
-
Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
-
SUZUKI Tsutomu
Department of Applied and Environmental Chemistry, Kitami Institute of Technology
-
YANAURA Saizo
Department of Pharmacology, School of Pharmacy, Hoshi University
-
Endou Hitoshi
Department Of Pharmacology Faculty Of Medicine University Of Tokyo
-
SAKAI Fuminori
Department of Pharmacology, Faculty of Medicine, University of Tokyo
-
AKIBA Isamu
Department of Chemistry and Biochemistry, The University of Kitakyushu
-
Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
-
Yanaura Saizo
Department Of Pharmacology School Of Pharmacy Hoshi University
-
Sakai Fuminori
Department Of Pharmacology Faculty Of Medicine University Of Tokyo
-
Akiba Isamu
Department Of Chemistry And Biochemistry The University Of Kitakyushu
-
Akiba Isamu
Department Of Pharmacology School Of Pharmacy Hoshi University
-
Yanaura Saizo
Department Of Pharmacology Hoshi College Of Pharmacy
-
Yanaura Saizo
Department Of Applied Pharmacology School Of Pharmacy Hoshi University
-
Suzuki Tsutomu
Department Of Pharmacology School Of Pharmacy Hoshi University
-
Suzuki Tsutomu
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
-
ENDOU Hitoshi
Department of Pharmacology, Faculty of Medicine, University of Tokyo
-
Akiba Isamu
Department of Applied Chemistry, Faculty of Technology, Tokyo University of Agriculture and Technology
関連論文
- Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
- Inhibition of L-Type Amino Acid Transporter Modulates the Expression of Cell Cycle Regulatory Factors in KB Oral Cancer Cells
- Children's toxicology from bench to bed - Drug-induced Renal Injury (3) : Drug transporters and toxic nephropathy in childhood
- EFFECTS OF Mg AND K DEFICIENCY ON MALE AND FEMALE MICE
- Establishment and Characterization of Mammalian Cell Lines Stably Expressing Human L-Type Amino Acid Transporters
- Nickel-catalyzed carbonization of wood for coproduction of functional carbon and fluid fuels II : improved fuel quality of oil fraction and increased heating value of gas fraction
- Nickel-catalyzed carbonization of wood for coproduction of functional carbon and fluid fuels I : production of crystallized mesoporous carbon
- Preparation of Crystallized and Mesoporous Carbon by Nickel-catalyzed Carbonization of Wood
- Electromagnetic Shielding Capacity of Wood Char Loaded with Nickel
- Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
- L-Type Amino Acid Transporter-1 Expressed in Human Astrocytomas, U343MGa(Biochemistry)
- Transport of methylmercury through the epithelial type amino acid transport system B^0(Proceedings of the 32nd Annual Meeting)
- P7-56 Identification of novel system L transporters and their methyl mercury-cysteine conjugates transport properties(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P7-20 Modulatory effects of membrane proteins interacting with essential large neutral amino acids transporter LAT1, on amino acid uptake in bladder transitional cell carcinoma line, T24(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTO
- Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver
- Gastric Tube Interposition for Corrosive Esophagitis Associated with Pyloric Stenosis
- P-21 Trasport of methyl mercury-cysteine conjugate by multispecific organic anion transport 3(Proceedings of the 27th Annual Meeting)
- Establishment of a Mouse Macula Densa Cell Line with an nNOS Promoter Driving EGFP Expression
- Mouse Organic Anion Transporter 2 (mOat2) Mediates the Transport of Short Chain Fatty Acid Propionate
- Nicergoline Enhances Glutamate Uptake via Glutamate Transporters in Rat Cortical Synaptosomes(Highlighted paper selected by Editor-in chief)(Pharmacology)
- Measurement of Glutamate Uptake and Reversed Transport by Rat Synaptosome Transporters(Pharmacology)
- Correlation of angiogenesis with ^F-FMT and ^F-FDG uptake in non-small cell lung cancer
- Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung
- L-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
- Nephrin and Podocin Expression Around the Onset of Puromycin Aminonucleoside Nephrosis
- RELATIONSHIP BETWEEN γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY IN URINE AND RENAL PROXIMAL TUBULAR DAMAGE(S) BY NEPHROTOXIC AGENTS (The 6th Meeting for the Study of Toxic Effect)
- SUPPRESSIVE EFFECT OF DIPYRIDAMOLE ON THE PROTEINURIA OF AMINONUCLEOSIDE NEPHROSIS IN RAT.
- EFFECTS OF MERCURY ON THE STRUCTURAL GLYCOPROTEINS OF VARIOUS SEGMENTS IN ISOLATED NEPHRON (The 5th Meeting for the Study of Toxic Effect)
- EFFECTS OF MERCURY ON THE STRUCTURAL PROTEINS OF VARIOUS SEGMENTS IN ISOLATED NEPHRON (The Fourth Meeting for the Study of Toxic Effect)
- 215. TOXIC ACTION OF HEAVY METALS. 2. ANALYSIS OF PROTEINURIA DUE TO MERCURY (The Third Meeting for the Study of Toxic Effect)
- 103. EFFECT OF MERCURY ON THE NEWT KIDNEY (The Second Meeting for the Study of Toxic Effect)
- PROGRESS IN NEPHROTOXICOLOGY : FROM IN VIVO SCREENING TEST TO MOLECULAR MECHANISMS
- Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
- Expression of Human Organic Anion Transporters in the Choroid Plexus and Their Interactions With Neurotransmitter Metabolites
- Role of Organic Anion Transporters in the Tubular Transport of Indoxyl Sulfate and the Induction of its Nephrotoxicity.(GENERAL SESSION BY POSTER PRESENTATION)(KIDNEYS AND URINARY EXCRETION SYSTEM)
- Morphine, Oxycodone, and Fentanyl Exhibit Different Analgesic Profiles in Mouse Pain Models
- S2-3 Opiate Psychotoxicity : role of NMDA recepter subunits and protein kinase C(Proceedings of the 27th Annual Meeting)
- Differential Expression of System L Amino Acid Transporters during Wound Healing Process in the Skin of Young and Old Rats(Molecular and Cell Biology)
- O-58 Transport of a methylmercury-cysteine conjugate mediated by system L neutral amino acid transporters(Proceedings of the 27th Annual Meeting)
- 1SE1020 Genetic code extension and establishment by aminoacyl-tRNA synthetase and tRNA modification enzymes(1SE Recent Advances in Structural Analyses of Funcitonal Mechanisms Based on Dynamics of Biological Reactions,The 48th Annual Meeting of the Biophy
- Human Organic Anion Transporters Mediate the Transport of Tetracycline
- BEHAVIORAL CHANGES IN MORPHINE-TOLERANT MICE
- STUDIES ON DRUG DEPENDENCE (REPT. 72) BRAIN MORPHINE LEVELS OF DEPENDENT MICE BY DAF (DRUG-ADMIXED FOOD) METHOD
- STUDIES ON DRUG DEPENDENCE (REPT. 52) INDUCTION OF MORPHINE DEPENDENT MICE BY DAF (DRUG-ADMIXED FOOD) METHOD
- C-17 IDENTIFICATION OF A NOVEL LIVER SPECIFIC ORGANIC ANION TRANSPORTER SELECTIVE FOR CONJUGATED DRUGS AND STEROID HORMONES
- Testicular Toxicology of Pubescent and Adult Rats Prenatally Exposure to 3,3',4,4',5-Pentachlorobiphenyl
- Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats
- TRK-820, a Selective к-Opioid Agonist, Produces Potent Antinociception in Cynomolgus Monkeys
- INTERACTION BETWEEN MU AND KAPPA RECEPTORS IN PHARMACOLOGICAL EFFECTS OF TOLERANCE TO AND DEPENDENCE ON SEVERAL OPIOIDS
- High Electroconductivity of Wood Char Obtained by Iron-catalyzed Carbonization
- The role of amino acid transporters in the cytotoxicity of methylmercury.(GENERAL SESSION BY POSTER PRESENTATION)(ENVIRONMENTAL CHEMICALS,HEAVY METALS & CYTOTOXICITY)
- O10-17 Expression of system L amino acid transporters in the blood-tissue barriers and the transport of 35^S-methylmercury.
- Role of Mouse Organic Anion Transporter 3 (mOat3) as a Basolateral Prostaglandin E_2 Transport Pathway
- Human Organic Anion Transporter 4 Is a Renal Apical Organic Anion/Dicarboxylate Exchanger in the Proximal Tubules
- Antinociceptive Effect of the Combination of Pentazocine With Morphine in the Tail-Immersion and Scald-Pain Tests in Rats
- Recent Advances in the Search for the μ-Opioidergic System : Endomorphin-induced Motivational Effect : Differential Mechanism of Endomorphin-1 and Endomorphin-2
- BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells(Molecular and Cell Biology)
- FUNCTIONAL PROPERTIES OF MULTISPECIFIC AMINO ACID TRANSPORTERS AND THEIR IMPLICATIONS TO TRANSPORTER-MEDIATED TOXICTY
- Organic Anion Transporter Family : Current Knowledge
- System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells
- Purinoceptor-Mediated Calcium Mobilization and Cellular Proliferation in Cultured Bovine Corneal Endothelial Cells
- Molecular biology of multispecific organic anion transporter family (OAT family)
- 22D-09-3 Silica increases cytosolic calcium and causes cell injury in renal cell lines.
- COMPARISON OF PHARMACOLOGICAL PROPERTIES BETWEEN PENTAZOCINE AND HOMOBENZOMORPHAN DERIVATIVES
- STUDIES ON THE MECHANISM OF INTERACTION BETWEEN METHAMPHETAMINE AND QUININE IN RATS
- Thoracic Esophagectomy Combined with Pylorus-Preserving Pancreatoduodenectomy in a One-Stage Procedure : Report of a Case
- A Novel Screening System for Self-mRNA Targeting Proteins
- Effects of hexavalent chromium on lipid peroxidation and hydroxyl radical generation in mouse kidney.
- Functional Characterization and Immunohistochemical Localization of Organic Anion Transporter 1 (S1c22a6) from Mouse Kidney
- NARCOTIC PHYSICAL DEPENDENCE AND URINARY SEX-DEPENDENT LOW MOLECULAR WEIGHT PROTEINS IN MALE RATS
- Current Status and Future Perspective on Molecular Toxicology (KEYNOTE LECTURE) (Proceedings of the 30th Annual Meeting)
- B-12 EFFECT OF MERCURY CHLORIDE ON ANGIOTENSIN II-INDUCED [Ca^]_i INCREASE IN RAT EARLY PROXIMAL TUBULE
- Cis-platinum(II)-diamino dichloride(CDDP) induced toxicity in immortalized cell lines established from each nephron segment of transgenic mice harboring ts-SV40 T-antigen gene.
- Implication of the Descending Dynorphinergic Neuron Projecting to the Spinal Cord in the (+)-Matrine-and (+)-Allomatrine-Induced Antinociceptive Effects(Medicinal Chemistry)
- Combined Effects of Psychostimulants and Morphine on Locomotor Activity in Mice
- Recent Advances in the Search for the μ-Opioidergic System : Differential Mechanism of G-Protein Activation Induced Endogenous μ-Opioid Peptides, Endomorphin and β-Endomorphin
- Modulation of the Discriminative Stimulus Effects of Cocaine and Methamphetamine by the Histaminergic System
- Evaluation of the Histamine H_1-Antagonist-Induced Place Preference in Rats
- Interaction between Discriminative Stimulus Effects of Cocaine and Morphine
- Roles of glutamate transporters in neuronal cell death
- W2-1 SIGNIFICANCE OF ALTERNATIVE TOXICITY TESTING
- Human Nramp2 as a cadmium transporter.(GENERAL SESSION BY POSTER PRESENTATION)(ENVIRONMENTAL CHEMICALS,HEAVY METALS & CYTOTOXICITY)
- EVALUATION OF NEPHROTOXICITY
- DISTRIBUTION AND SOME CHARACTERISTICS OF CYTOCHROME P-450 IN THE KIDNEY
- "C-14 The intracellular mechanism for cisplatin-induced apoptosis in renal cell line
- 1P014 Snapshots of tRNA sulfuration via an adenylated intermediate(1. Protein structure and dynamics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- L-Type amino acid transporter 1 inhibitors inhibit tumor cell growth
- Interactions of Human-and Rat-Organic Anion Transporters With Pravastatin and Cimetidine
- Transport of ochratoxin A by renal multispecific organic anion transporter 1 and its effect on cell proliferation
- Design and Simulation of 4Q-Multiplier Using Linear and Saturation Regions of MOSFET Complementally(Special Section on Papers Selected from ITC-CSCC 2001)
- Interactions of Human Organic Anion Transporters With Aristolochic Acids
- DISTRIBUTION OF GAMMA-GLUTAMYL TRANSPEPTIDASE AND GLUTAMINASE ISOENZYMES IN THE RABBIT SINGLE NEPHRON
- MICROPUNCTURE STUDY OF PROTEIN CONCENTRATION IN GLOMERULAR FLUID IN THE NEWT
- CYTOCHROME P-450 MONOOXYGENASE SYSTEM IN THE RABBIT KIDNEY: ITS INTRANEPHRON LOCALIZATION AND ITS INDUCTION
- Interactions of Human Organic Anion Transporters With Aristolochic Acids
- Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease
- Human urate transporter 1 (hURAT1) mediates the transport of orotate
- Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
- Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
- A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A