Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
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概要
- 論文の詳細を見る
We analyzed the functional properties of five nonsynonymous single nucleotide polymorphisms (SNPs) in the sodium-phosphate transporter NPT4 gene (SLC17A3) using the Xenopus oocyte expression system. NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [14C]para-aminohippurate, [3H]bumetanide, [3H]estrone sulfate, and [14C]urate, when each variant clone was expressed in the plasma membrane of oocytes. This study suggests the possibility that the genetic variation of NPT4 contributes to inter-individual differences in disposition of anionic drugs such as diuretics as well as certain endogenous organic anions such as urate.
著者
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Endou Hitoshi
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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Anzai Naohiko
Department of Pharmacology and Toxicology, Kyorin University School of Medicine
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SAKURAI Hiroyuki
Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Med
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安西 尚彦
東京女子医科大学附属膠原病リウマチ･痛風センター
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安西 尚彦
杏林大学医学部薬理学教室
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Kimura Toru
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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Jutabha Promsuk
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Jutabha Promsuk
杏林大学 医学部薬理学
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Yamanaka Hisashi
Institute of Rheumatology, Tokyo Womens Medical University, Japan
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URANO Wako
Institute of Rheumatology, Tokyo Women's Medical University
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TANIGUCHI Atsuo
Institute of Rheumatology, Tokyo Women's Medical University
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Yamanaka Hisashi
Institute Of Reumatology Tokyo Women's Medical College
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Taniguchi Atsuo
Institute Of Rheumatology Aoyama Hospital Tokyo Women's Medical University
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Endou Hitoshi
Department Of Pharmacology & Toxicology Kyorin University School Of Medicine
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Urano Wako
Institute Of Rheumatology Tokyo Women's Medical University
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Sakurai Hiroyuki
Department Of Hepatobiliary Pancreatic And Transplant Surgery Graduate School Of Medicine Mie Univer
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Anzai Naohiko
Department Of Pharmacology And Toxicology Kyorin University School Of Medicine
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Kimura Toru
Department Of Neurology Rakuwakai Otowa Hospital
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Sakurai Hiroyuki
Department Of Biological & Chemical Engineering Gunma University
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