Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms

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概要

• 論文の詳細を見る

• We analyzed the functional properties of five nonsynonymous single nucleotide polymorphisms (SNPs) in the sodium-phosphate transporter NPT4 gene (SLC17A3) using the Xenopus oocyte expression system. NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [14C]para-aminohippurate, [3H]bumetanide, [3H]estrone sulfate, and [14C]urate, when each variant clone was expressed in the plasma membrane of oocytes. This study suggests the possibility that the genetic variation of NPT4 contributes to inter-individual differences in disposition of anionic drugs such as diuretics as well as certain endogenous organic anions such as urate.

著者

• Endou Hitoshi

  Department of Pharmacology and Toxicology, Kyorin University School of Medicine

• Anzai Naohiko

  Department of Pharmacology and Toxicology, Kyorin University School of Medicine

• SAKURAI Hiroyuki

  Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Med

• 安西 尚彦

  東京女子医科大学附属膠原病リウマチ･痛風センター

• 安西 尚彦

  杏林大学医学部薬理学教室

• Kimura Toru

  Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan

• Jutabha Promsuk

  Department Of Pharmacology And Toxicology Kyorin University School Of Medicine

• Jutabha Promsuk

  杏林大学 医学部薬理学

• Yamanaka Hisashi

  Institute of Rheumatology, Tokyo Womens Medical University, Japan

• URANO Wako

  Institute of Rheumatology, Tokyo Women's Medical University

• TANIGUCHI Atsuo

  Institute of Rheumatology, Tokyo Women's Medical University

• Yamanaka Hisashi

  Institute Of Reumatology Tokyo Women's Medical College

• Taniguchi Atsuo

  Institute Of Rheumatology Aoyama Hospital Tokyo Women's Medical University

• Endou Hitoshi

  Department Of Pharmacology & Toxicology Kyorin University School Of Medicine

• Urano Wako

  Institute Of Rheumatology Tokyo Women's Medical University

• Sakurai Hiroyuki

  Department Of Hepatobiliary Pancreatic And Transplant Surgery Graduate School Of Medicine Mie Univer

• Anzai Naohiko

  Department Of Pharmacology And Toxicology Kyorin University School Of Medicine

• Kimura Toru

  Department Of Neurology Rakuwakai Otowa Hospital

• Sakurai Hiroyuki

  Department Of Biological & Chemical Engineering Gunma University

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