EFFECT OF NMDA RECEPTOR ANTAGONISTS ON PROTEIN KINASE ACTIVATED BY CHRONIC MORPHINE TREATMENT
スポンサーリンク
概要
- 論文の詳細を見る
In a previous study we indicated the involvement of the N-methyl-D-aspartate (NMDA) receptor in the development of morphine dependence as assessed by naloxone-induced rise in norepinephrine release in chronically morphine-treated rats. In the present experiments, we studied (1) the possible role of protein kinases in the increased norepinephrine release occurring after naloxone injection and (2) the effects of NMDA receptor antagonists on chronic morphine exposure-induced changes in protein kinase activity. The naloxone-induced rise in norepinephrine release was attenuated by concomitant administration of a protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine hydrochloride (H-7) or an NMDA receptor antagonist, (+)-5-methyl-10, 11-dihydro-5H-dibenzo[a,d]-cyclohepten-5, 10-imine hydrogen maleate (dizocilpine, MK-801) with morphine. Both cAMP-dependent protein kinase (PKA) and protein kinase C (PKC), which mediate neurotransmitter release, were clearly activated in the cytosol of the pons/medulla, but not in that of the hippocampus, in chronically morphine-treated rats. This activation of PKA and PKC by chronic morphine treatment was inhibited by infusion of dizocilpine or D(-)-2-amino-5-phosphonopentanoic acid (AP-5), an ionotropic glutamate receptor antagonist, together with morphine. These results suggest that NMDA receptor antagonists inhibit the increase in protein kinase activity produced by chronic morphine treatment, thus suppressing the naloxone-induced rise in norepinephrine release.
- 日本トキシコロジー学会の論文
- 1997-02-25
著者
-
FUKUDA Hideomi
Department of Pharmacology, College of Pharmacy, Nihon University
-
Fukuda H
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
-
Fukuda Hitoshi
Research Laboratories Toyama Chemical Co. Ltd.
-
Fukuda H
Clinical Research Department Toyama Chemical Co. Ltd.
-
MAKIMURA Mizue
Department of Pharmacology, College of Pharmacy, Nihon University
-
IWAI Miho
Department of Pharmacology, College of Pharmacy, Nihon University
-
SUGIMOTO Hideya
Department of Pharmacology, College of Pharmacy, Nihon University
-
Iwai Miho
Department Of Pharmacology College Of Pharmacy Nihon University
-
Makimura M
Department Of Pharmacology College Of Pharmacy Nihon University
-
Makimura Mizue
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(present
-
Sugimoto Hideya
Department Of Pharmacology College Of Pharmacy Nihon University
-
FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
関連論文
- Comparative study of survival signal withdrawal- and 4-hydroxynonenal-induced cell death in cerebellar granule cells
- EFFECTS OF VALPROIC ACID ON SPINAL REFLEXES AND [^3H]MUSCIMOL AND [^3H]DIAZEPAM BINDING IN BRAIN MEMBRANES IN RATS
- IMPAIRMENT OF VISUAL SYSTEM OF BEAGLES ORALLY INGESTING CLIOQUINOL
- DETERIORATION OF SPINAL REFLEX IN BEAGLES ORALLY INGESTING CLIOQUINOL
- CENTRALLY SPECIFIC AND GABA-INSENSITIVE INHIBITION OF BENZODIAZEPINE BINDING BY PROSTAGLANDINS (A_1,A_2 AND B_2)
- γ-AMINOBUTYRIC ACID AND BENZODIAZEPINE RECEPTOR INTERACTION
- EFFECTS OF BARBITURATES ON THE DECEREBRATE RIGIDIIY IN RATS
- QT PRODACT : Evaluation of the Potential of Compounds to Cause QT Interval Prolongation by Action Potential Assays Using Guinea-Pig Papillary Muscles
- QT PRODACT : A Multi-site Study of In Vitro Action Potential Assays on 21 Compounds in Isolated Guinea-Pig Papillary Muscles
- Structure-Activity Relationships of Phenylethylamine Analogs in Their Serotonergic Depressant Effects on the Spinal Monosynaptic Reflex in Rats
- Enhancement of Spinal Monosynaptic Reflexes with Phenylethylamine and Related Drugs through Descending Noradrenergic Neurons
- Molecular Complex Consisting of Two Typical External Medicines: Intermolecular Interaction between Indomethacin and Lidocaine
- Roles of γ-Aminobutyric Acid_B (GABA_B) and γ-Hydroxybutyric Acid Receptors in Hippocampal Long-Term Potentiation and Pathogenesis of Absence Seizures
- Pharmacological profiles of generalized absence seizures in lethargic, stargazer and γ-hydroxybutyrate-treated model mice
- PHARMACOLOGICAL EVALUATION OF GARENOXACIN, A NOVEL DES-F(6)-QUINOLONE ANTIMICROBIAL AGENT : EFFECTS ON THE CENTRAL NERVOUS SYSTEM
- EFFECT OF NMDA RECEPTOR ANTAGONISTS ON PROTEIN KINASE ACTIVATED BY CHRONIC MORPHINE TREATMENT
- INHIBITORY EFFECT OF THE NMDA RECEPTOR ANTAGONIST, DIZOCILPINE (MK-801), ON THE DEVELOPMENT OF MORPHINE DEPENDENCE
- SPINAL REFLEXES IN CHINOFORM-ADMINISTERED RATS
- SPINAL REFLEXES IN RATS SUFFERED FROM MOTOR INCOORDINATION BY CHINOFORM
- Effects of quinolone antibacterial agents and related compounds on GABA_A receptor chloride ion channels.
- DETERIORATION OF SPINAL REFLEX IN QUAILS ORALLY INGESTING CLIOQUINOL
- EFFECTS OF METABOLIC INHIBITORS AND OUABAIN ON STATIC AFFERENT DISCHARGES FROM THE ISOLATED FROG MUSCLE SPINDLE
- Assessment of Japanese Pharmacists' Perceptions towards Community Pharmacy
- k-Opioid Agonists Do Not Inhibit Adenylate Cyclase
- EFFECTS OF CENTRALLY ACTING MUSCLE RELAXANTS ON THE ANEMIC DECEREBRATE RIGIDITY IN RATS
- EFFECT OF BACLOFEN ON THE γ-MOTOR ACTIVITY IN THE RAT
- MODE OF ACTION OF L-DOPA ON γ-MOTOR SYSTEM IN THE RAT
- Effects of Repeated Administration of a κ-Opioid Agonist on Phorbol Ester Binding to Membrane-Bound Protein Kinase C in Rat Brain
- ANTICONVULSANT ACTION OF DIAZEPAM IN MICE PRETREATED WITH CAFFEINE
- POSTNATAL DEVELOPMENT OF THE BENZODIAZEPINE AND GABA RECEPTORS IN THE RAT SPINAL CORD
- POSTNATAL DEVELOPMENT OF THE GABA SYSTEM IN THE RAT SPINAL CORD
- Optimum Conditions for Derivatization of Glutathione, Cysteine and Cysteinylglycine in Human Plasma with Ammonium 7-Fluorobenzo-2-Oxa-1,3-Diazole-4-Sulfonate for Accurate Quantitation by High-Performance Liquid Chromatography
- EFFECTS OF ANTICHOLINERGICS ON THE AFFERENT DISCHARGES FROM THE MUSCLE SPINDLE OF THE BULLFROG IN VITRO
- EFFECTS OF ZOPICLONE AND BENZODIAZEPINES ON SPINAL REFLEXES, ANEMIC DECEREBRATE RIGIDITY AND BENZODIAZEPINE BINDING
- Muscle relaxation mediated by central alpha_2-agonistic action in decerebrate rigidity in rats
- PHARMACOLOGICAL EVALUATION OF MUSCLE RELAXANTS
- DECREASE IN EFFECTS OF MUSCIMOL ON THE DORSAL ROOT AFTER REPEATED ADMINISTRATION OF DIAZEPAM IN RATS
- MECHANISMS OF DEPRESSANT ACTION OF MUSCLE RELAXANTS ON SPINAL REFLEXES : PARTICIPATION OF MEMBRANE STABILIZING ACTION
- EXCITATION BY LYONIOL-A OF VAGAL AFFERENT NERVES AND THE REFLEX AUTONOMIC AND SOMATIC ACTIONS IN RATS
- THE EFFECT OF DENERVATION ON THE CYCLIC NUCLEOTIDES LEVELS OF THE VAS DEFFERENS
- EFFECTS OF EXCITATORY TRANSMITTER CANDIDATES ON FROG SPINAL MOTOR FUNCTION
- ALTERATIONS IN SPONTANEOUS ACTIVITY OF THE ISOLATED FROG SPINAL CORD IN CALCIUM-FREE ENVIRONMENT
- ALTERATION OF EXTRACELLULAR K+-ACTIVITY INDUCED BY AMINO ACIDS IN THE FROG SPINAL CORD
- RIGIDITY IN RATS DUE TO ANEMIC DECEREBRATION AND THE EFFECT OF CHLORPROMAZINE
- EFFECT OF LYONIOL-A ON DECEREBRATE RIGIDITY AND ELECTROENCEPHALOGRAM IN RATS
- SPONTANEOUS ELECTRICAL ACTIVITY OF THE BULLFROG SPINAL CORD AND SUSCEPTIBILITY TO SOME CENTRALLY ACTING DRUGS AND AMINO ACIDS
- Amphetamine-Antagonistic Property of 4-Phenyltetrahydroisoquinoline: Effect on Noradrenaline Release in Spinal Cord Slices.
- 2-Phenylethylamine and methamphetamine enhance the spinal monosynaptic reflex by releasing noradrenaline from the terminals of descending fibers.
- Effects of pentobarbital on (3H)diazepam binding in the cerebral cortex, cerebellum and spinal cord of developing rats.
- Effect of the Centrally Acting Muscle Relaxant Tizanidine on Spinal Reflexes: Involvement of Descending Noradrenergic Systems.
- Spinal .ALPHA.1- and .ALPHA.2-adrenoceptors mediate facilitation and inhibition of spinal motor transmission, respectively.