Spinal .ALPHA.1- and .ALPHA.2-adrenoceptors mediate facilitation and inhibition of spinal motor transmission, respectively.
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概要
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The role of descending noradrenergic fibers in the spinal motor systems was investigated using spinal reflexes in acutely spinalized rats. In rats pretreated with the MAO inhibitor clorgyline-HCl (1 mg/kg, i.v.), L-3, 4-dihydroxyphenylalanine (L-dopa) (5 mg/kg, i.v.), a precursor of dopamine and noradrenaline, markedly potentiated the mono- (MSR) and polysynaptic reflexes (PSR). Selective blockade of α<SUB>1</SUB>-adrenoceptors by pretreatment with prazosin-HCl abolished these facilitatory effects on the MSR and the PSR and revealed the inhibitory effect of L-dopa on the PSR. The depression of PSR was antagonized by the α<SUB>2</SUB>-antagonist piperoxan. Clonidine-HCl (0.05 mg/kg, i.v.), a so-called α<SUB>2</SUB>-agonist, and tizanidine-HCl (0.1 mg/kg, i.v.) decreased the MSR and the PSR in rats pretreated with prazosin. These inhibitions were antagonized by piperoxan. These results suggest that α<SUB>1</SUB>- and α<SUB>2</SUB>-adrenoceptors mediate facilitation and attenuation of motor transmission in the rat spinal cord, respectively.
- 公益社団法人 日本薬理学会の論文
著者
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Tanabe Mitsuo
Department Of Pharmacology Saitama Medical School
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Ono Hideki
Department Of Cardiology Ninon University Surugadai Hospital
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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TANABE Mitsuo
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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