Amphetamine-Antagonistic Property of 4-Phenyltetrahydroisoquinoline: Effect on Noradrenaline Release in Spinal Cord Slices.
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概要
- 論文の詳細を見る
The amphetamine-related compounds methamphetamine, phenylethylamine and nomifensine increased the K<SUP>+</SUP>-evoked release of endogenous noradrenaline from rat spinal cord slices. 4-Phenyl-1, 2, 3, 4-tetrahydroisoquinoline (4PTIQ), which alone did not affect the K<SUP>+</SUP>-evoked release of noradrenaline, inhibited the noradrenaline-releasing effects of methamphetamine, phenylethylamine and nomifensine. 4PTIQ revealed a weak noradrenaline-uptake inhibitory effect, and the effect was weaker than those of desipramine and nomifensine. These results showed that 4PTIQ is an antagonist against the amine-releasing effects of amphetamines.
- 公益社団法人 日本薬理学会の論文
著者
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Nagao Taku
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Satoh Mitsutoshi
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Ono Hideki
Department Of Cardiology Ninon University Surugadai Hospital
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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Ohta Shigeru
Dppartment of Bioorganic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo
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Hirobe Masaaki
Dppartment of Bioorganic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Tokyo
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Satoh Mitsutoshi
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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