Diltiazem Ameliorates Contractile Dysfunction Without Shortening of Action Potential Duration in Ischemic Heart of Anesthetized Dogs
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概要
- 論文の詳細を見る
The purpose of the following experiment was to determine whether amelioration of myocardial contractile dysfunction by diltiazem is mediated by shortening of monophasic action potential duration (MAPD) during myocardial ischemia in anesthetized dogs. Diltiazem improved regional contraction during reperfusion after 10-min occlusion. The shortening of MAPD and increase in [K+]e were blunted by treatment with diltiazem. These results suggest that shortening of action potential duration during myocardial ischemia is unlikely to be a reason for the amelioration of contractile dysfunction.
- 社団法人 日本薬理学会の論文
- 2001-06-01
著者
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NAGAO Taku
Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, The Universit
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Yamazaki Jun
Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Japan
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Nagao Taku
Laboratory Of Pharmacology & Toxicology Graduate School Of Pharmaceutical Sciences The Universit
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Nagao Taku
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Nagao T
Laboratory Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences University Of T
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Yamazaki J
Fukuoka Dental Coll. Fukuoka Jpn
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Nagao T
Univ. Tokyo Tokyo Jpn
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HAMADA Kaori
Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, University of
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Hamada Kaori
Laboratory Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences University Of T
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Yamazaki Jun
Department Of Pharmacology Fukuoka Dental College
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