Barium Activates Rat Cerebellar Nitric Oxide Synthase
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概要
- 論文の詳細を見る
Ba<SUP>2+</SUP> is known to pass through <I>N</I>-methyl-<SUB>D</SUB>-aspartate receptor channels and cause an increase in cGMP levels in rat cerebella. In the present study, we compared the activation of rat cerebellar nitric oxide synthase (NOS) by Ba<SUP>2+</SUP> with that produced by Ca<SUP>2+</SUP>. Both cations stimulated L-citrulline formation in the presence of calmodulin in identical fractions eluted from an anion exchange column with a salt gradient. EC<SUB>50</SUB> values for Ca<SUP>2+</SUP> and Ba<SUP>2+</SUP> were 200 nM and 50 μM, respectively. The IC<SUB>50</SUB> of N<SUP>G</SUP>-monomethyl-L-arginine was the same (200 nM). These indicate a possible action of Ba<SUP>2+</SUP> on NOS through the calmodulin-dependent pathway.
- 社団法人 日本薬理学会の論文
- 1996-04-01
著者
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Yamazaki Jun
Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Japan
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Nagao Taku
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Urushidani Tetsuro
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Yamazaki Jun
Department Of Pharmacology Fukuoka Dental College
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Yamazaki Jun
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Urushidani Tetsuro
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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