Quaternary Diltiazem Can Act from Both Sides of the Membrane in Ventricular Myocytes.
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概要
- 論文の詳細を見る
A quaternary derivative of diltiazem (quat-DTZ)was tested to determine whether diltiazem approaches L-type Ca<SUP>2+</SUP> channels from the outside or inside of the cell membrane. In single ventricular myocytes, both extra and intracellular application of quat-DTZ effectively blocked the L-type Ca<SUP>2+</SUP> channel current, whereas D890 was effective only when applied intracellularly. These results strongly suggest that diltiazem binds to the channel from the outside as well as the inside of the membrane in a manner different from that of phenylalkylamines.
著者
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Nagao Taku
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Adachi-Akahane Satomi
Department of Pharmacology, School of Medicine, Faculty of Medicine, Graduate School of Medical Sciences, Toho University
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Okuyama Ryo
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Amano Yukiko
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Adachi-Akahane Satomi
Department of Pharmacology, Faculty of Medicine, Toho University
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