Phenoxybenzamine Discriminates Between Two Distinct Populations of Histamine H1-Receptors in Longitudinal Muscle of Guinea-pig Ileum.
スポンサーリンク
概要
- 論文の詳細を見る
The longitudinal muscle of guinea-pig ileum was used as a test tissue. Progressive (up to 70 min) treatment with phenoxybenzamine (10<SUP>-6</SUP> M) inhibited progressively the response to histamine and progressively decreased the density of histamine H<SUB>1</SUB>-receptors. However, the 90 min treatment has no further significant inhibitory effect on the contractile response and did not decrease the density of the receptors. These results suggest that phenoxybenzamine discriminates between two distinct populations of H<SUB>1</SUB>-receptors. Furthermore, it was found that the presence of GTP<SUB>γ</SUB>-S made some populations of H<SUB>1</SUB>-receptors resistant to phenoxybenzamine and facilitated an interaction of mepyramine with H<SUB>1</SUB>-receptors.
- 日本平滑筋学会の論文
著者
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Satoh Mitsutoshi
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Hosoki Rumiko
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Shinkai Michiko
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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HOSOKI Rumiko
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Science
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OKAYASU Ayako
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Science
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