SPECIFIC <SUP>3</SUP>H-HALOPERIDOL BINDING TO DOPAMINE RECEPTORS IN THE ANTERIOR BYSSUS RETRACTOR MUSCLE OF <I>MYTILUS EDULIS</I>
スポンサーリンク
概要
- 論文の詳細を見る
The anterior byssus retractor muscle (ABRM) of <I>Mytilus edulis</I> has specific dopamine receptors. We carried out a radioligand binding assay for dopamine receptors in ABRM using (<SUP>3</SUP>H)-haloperidol as the radioligand. High affinity binding of (<SUP>3</SUP>H)-haloperidol has been shown. Scatchard analysis showed a single component of binding with an apparent equilibrium constant (K<SUB>D</SUB>) of 1.6 nM and a maximal number of binding sites (Bmax) of 219 fmoles/mg protein. Some dopamine antagonists displaced 3 nM (<SUP>3</SUP>H)-haloperidol binding, and the IC50 and Ki-value of these drugs were calculated. Considering these results, this muscle is thought to be suitable for a study of the dopamine receptors.
- 社団法人 日本薬理学会の論文
著者
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Ishii Yumiko
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Ishii Yumiko
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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