PHYSIOLOGICAL CALCIUM ION CONCENTRATION AND A CHOLINERGIC DRUG ON ACTIVITY OF PARTICULATE GUANYLATE CYCLASE IN GUINEA PIG TAENIA CAECUM
スポンサーリンク
概要
- 論文の詳細を見る
The microsomal fraction derived from the taenia caecum of guinea pigs was used as a particulate guanylate cyclase preparation. The guanylate cyclase activity was not influenced by butyltrimethylammonium bromide and Ca^<2+> (4.0 to 24×10^<-7>M). The results suggest that the particulate guanylate cyclase is not activated by the drug-receptor interaction and also by the increase of intracellular Ca^<2+> concentration. Therefore, the increase of tissue level of cyclic GMP brought about in the guinea pig taenia caecum might be due to activation of soluble guanylate cyclase following the increase in the intracellular Ca^<2+> concentration.
- 公益社団法人日本薬学会の論文
著者
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Hisayama Tetsuhiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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HISAYAMA Tetsuhiro
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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