RELATIONSHIP BETWEEN SYNAPTOSOMAL CALCIUM UPTAKE AND ANTINOCICEPTIVE ACTION OF MORPHINE
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概要
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We studied the relationship between inhibition of <SUP>45</SUP>Ca<SUP>2+</SUP> uptake and the antinociceptive action induced by morphine and effects of papaverine and 1, 1-diphenyl-3-piperidinobutanol hydrochloride (Aspaminol) on both these actions of morphine. Addition of these drugs in the incubation medium significantly inhibited glutamate-stimulated synaptosomal <SUP>45</SUP>Ca<SUP>2+</SUP> uptake. The inhibition curves of morphine and Aspaminol on glutamate-stimulated synaptosomal <SUP>45</SUP>Ca<SUP>2+</SUP> uptake were linear, but that of papaverine was not. The inhibition of morphine on synaptosomal <SUP>45</SUP>Ca<SUP>2+</SUP> uptake was reversed by addition of naloxone. The inhibition of synaptosomal <SUP>45</SUP>Ca<SUP>2+</SUP> uptake induced by morphine was increased by the simultaneous addition of Aspaminol, but the inhibition induced by both morphine and papaverine was not increased to more than that by papaverine alone. Since morphine-antinociception was potentiated by Aspaminol and blocked by papaverine, these results support that the inhibition of synaptosomal calcium uptake plays an important role in the production of morphine-antinociception. However, since the inhibition of synaptosomal <SUP>45</SUP>Ca<SUP>2+</SUP> uptake by morphine was less than that by both Aspaminol and papaverine, and papaverine blocked morphine-anti nociception, notwithstanding that 10<SUP>-4</SUP> M of papaverine alone completely inhibited glutamate-stimulated <SUP>45</SUP>Ca<SUP>2+</SUP> uptake into synaptosomes, it may be difficult to account for the antinociceptive action of morphine by the inhibition of <SUP>45</SUP>Ca<SUP>2+</SUP> uptake only.
- 社団法人 日本薬理学会の論文
著者
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Konno Fukio
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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KONNO FUKIO
Department of Biology, Faculty of Science, Kobe University
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