EFFECT OF ACETYLCHOLINE ON DESENSITIZATION OF ISOLATED RAT TRACHEA TO 5-HYDROXYTRYPTAMINE —A POSSIBLE ALLOSTERIC INTERACTION BETWEEN DRUG RECEPTORS
スポンサーリンク
概要
- 論文の詳細を見る
It is well known that desensitization of smooth muscle preparations occurs by repeated exposure to a stimulating drug. This is called tachyphylaxis. This paper demonstrates the response of isolated rat tracheal muscle to 5-hydroxytryptamine (5-HT) as being diminished by repeated application in almost every instance and that 5-HT applied in the presence of stimulating drugs caused a further contraction when the preparation did not respond to 5-HT alone. For this reason interaction between 5-HT and other stimulating drugs was studied on the rat tracheal muscle after desensitization had occurred.
- 社団法人 日本薬理学会の論文
著者
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Ishida Yukisato
Department Of Molecular And Cellular Physiology University Of Cincinnati College Of Medicine
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ISHIDA Yukisato
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences University of Tokyo
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