THE EFFECTS OF EXTERNAL DIVALENT CATIONS ON HISTAMINE-RECEPTOR INTERACTION
スポンサーリンク
概要
- 論文の詳細を見る
The effects of external divalent cations on drug-receptor interaction were examined using guinea pig taenia. The effects of histamine on membrane potential of taenia in various solutions were also examined using the sucrose gap method.<BR>Ca<SUP>2+</SUP> and Me<SUP>2+</SUP> played an important role in the combination of histamine with its receptor. Sr<SUP>2+</SUP>, Mn<SUP>2+</SUP> and Co<SUP>2+</SUP> do not substitute for. Ca<SUP>2+</SUP> and Me<SUP>2+</SUP> in this interaction.<BR>None of divalent cations used were involved in the competitive antagonist-receptor interaction or in the irreversible antagonist-receptor interaction.<BR>Histamine which induced membrane depolarization and increased tension in normal Locke Ringer solution had no effect on the membrane potential and tension in Mg<SUP>2+</SUP>-free Se<SUP>2+</SUP>-solution. The mechanism for this phenomenon has been discussed herein.
- 公益社団法人 日本薬理学会の論文
著者
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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TAKAGI Keijiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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LIAO Chung
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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