EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS AND Ca-BLOCKER ON Ca-RELEASE AND Ca-BINDING IN MICROSOMAL FRACTIONS FROM RABBIT TAENIA COLI
スポンサーリンク
概要
- 論文の詳細を見る
Effects of nonspecific smooth muscle relaxants, papaverine (10<SUP>-4</SUP> M) and Aspaminol (1, 1-diphenyl-3-piperidinobutanol hydrochloride, 10<SUP>-4</SUP> M), and Ca-blocker, D-600 (10<SUP>-6</SUP> M) on Ca-release and Ca-binding in the microsomal fractions of rabbit taenia coli were determined. The doses necessary to relax the K-depolarized taenia coli maximally were used. Ca-binding in the microsomal fractions was inhibited by Aspaminol and D-600 and increased by papaverine in the concentration used. On the other hand, Ca-release from the Ca-incorporated microsomal fractions was inhibited by papaverine and Aspaminol but was not influenced by D-600. Changes observed in Ca-transfer may be related to relaxation of smooth muscle induced by the test drugs.
- 社団法人 日本薬理学会の論文
著者
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Hisayama Tetsuhiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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SUZUKI Sae
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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