EFFECTS OF PHENOBARBITAL ON PLASMA CONCENTRATION OF PHENYTOIN AND MORTALITY OF MICE TREATED WITH PHENYTOIN AFTER ELECTROSHOCK
スポンサーリンク
概要
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The effects of phenobarbital on the plasma concentration of phenytoin and mortality of the phenytoin-treated mice were mainly studied. The plasma concentration of phenytoin estimated in the live mice after electroshock was significantly higher than that in the dead mice, suggesting that biological activity of phenytoin is dependent on its plasma concentration where individual difference seems to be large. Though the pretreatment of mice with phenobarbital lowered the plasma concentration of phenytoin, all the mice were alive after electroshock with further treatment with phenobarbital and phenytoin. These results suggest that combination of phenobarbital with phenytoin for the treatment of epileptic patients may be feasible.
- 公益社団法人日本薬学会の論文
著者
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Watanabe Keiichi
Department Of Internal Medicine School Of Medicine Tokai University
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Takayanagi Issei
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Sakai Naomi
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Hisayama Tetsuhiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Watanabe Keiichi
Department Of Pharmacy Toho University Hospital
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KANEMATSU MIZUE
Department of Pharmacy, Toho University Hospital
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ASAI YUKO
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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KONDOH YOSHIKO
Department of Pharmacy, Toho University Hospital
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Kondoh Yoshiko
Department Of Pharmacy Toho University Hospital
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Asai Yuko
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Watanabe Keiichi
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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Kanematsu Mizue
Department Of Pharmacy Toho University Hospital
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