ALTERATION OF GLUTATHIONE-PEROXIDASE (GSH-PO) IN RAT VENTRAL PROSTATE : EFFECT OF CASTRATION AND TESTOSTERONE ADMINISTRATION
スポンサーリンク
概要
- 論文の詳細を見る
Immunocytochemical localization of glutathione-peroxidase (GSH-PO) in the ventral prostate was studied in rats under the following experimental conditions; 1) normal untreated 2) 4 weeks after castration 3) testosterone-administration to castrated, in order to clarify the role of GSH-PO. In normal untreated group, GSH-PO was predominantly observed in glandular epithelial cells of the ventral prostate. Intracellular localization of GSH-PO in the glandular epithelial cells was mainly observed in cytoplasmic matrix near the rough endoplasmic reticulum, and it was occasionally noted as a small granular structure at the supranuclear region. In the castrated animal, the intensity of GSH-PO staining in the glandular epithelial cells of atrophic prostate was markedly decreased . By testosterone-administration to the castrated animal, GSH-PO was clearly detected in the glandular epithelial cells of stimulated prostate. Intracellular localization was mainly observed in cytoplasmic matrix and the number of GSH-PO-positive granules increased remarkably as compared with those of other experimental groups. These findings strongly suggest that GSH-PO in the glandular epithelial cells of the rat ventral prostate is testosterone-dependent, and that its staining pattern is a useful marker for testosteronc action.
- 日本組織細胞化学会の論文
著者
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Watanabe K
Aoba Gakuen
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Watanabe Keiichi
Department Of Internal Medicine School Of Medicine Tokai University
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Suzuki R
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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MURAKOSHI Masanori
Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
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Murakoshi Masanori
Safety Res. Dept. Teikoku Hormone Mfg Co. Ltd.
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SUZUKI R.
Safety Research Department, Teikoku Hormone Mfg, Co. Ltd.
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Suzuki R.
Safety Research Department Teikoku Hormone Mfg. Co. Ltd.
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Watanabe Keiichi
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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