CORRELATION BETWEEN INTRAMITOCHONDRIAL LOCALIZATION OF GLUTATHIONE-PEROXIDASE (MITOCHONDRIAL GSH-PO) AND STEROIDOGENESIS IN THE RAT ADRENOCORTICAL CELLS
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概要
- 論文の詳細を見る
In order to confirm the relationship between mitochondrial GSH-PG and steroidogenesis in the rat adrenal cortex, we have studied the immunocytochemical localization of GSH-PO in the rat adrenocortical cells of Metopiron administration, which blocks the conversion of deoxycorticosterone to corticosterone. In the control rat adrenocortical cells, mitochondrial GSH-PO was mainly localized in lipid-depleted compact cells, of inner fasciculata cells, but not zona glomerulosa and zona reticularis cells. By Metopiron administration, the adrenal cortex was markedly hypertrophic. Immunohistochemically, GSH-PO was observed in outer fasciculata cells and intracellular localization of GSH-PO was mainly observed in cytosol (cytosol GSH-PO). However, mitochondrial GSH-PO was less than that in the control rat adrenocortical cells. Based on our findings, it is strongly suggested that mitochondrial GSH-PO may be a very important enzyme for steridogenesis, especially, corticosterone biosynthesis.
- 日本組織細胞化学会の論文
著者
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Osamura Yoshiyuki
Department of Pathology Tokai University School of Medicine
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YOSHIMURA Shinichi
Department of Neurosurgery, Graduate School of Medicine, Gifu University
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Osamura R
Department Of Pathology School Of Medicine Tokai University
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Watanabe Keiichi
Department Of Internal Medicine School Of Medicine Tokai University
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MURAKOSHI Masanori
Departments of Pathology, School of Medicine, Tokai University
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Yoshimura Shinichi
Departments Of Cell Biology Tokai University School Of Medicine
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Yoshimura S
Department Of Molecular Life Science (cell Biology Division) Tokai University School Of Medicine
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Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
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Murakoshi Masanori
Department Of Pathology School Of Medicine Tokai University
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Yoshimura Shinichi
Department Of Molecular Life Science Tokai University School Of Medicine
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Osamura Yoshiyuki
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
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Osamura Yoshiyuki
Department Of Internal Medicine Tokai University School Of Medicine
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Yoshimura Shinichi
Department Of Molecular Life Science (cell Biology) Tokai University School Of Medicine
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Watanabe Keiichi
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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Yoshimura Shinichi
Department of Molecular Life science (Cell Biology Division), Tokai University School of Medicine
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