Histopathological Analyses of Proliferative Potentials of Intracranial Meningiomas Using Bromodeoxyuridine and MIB-1 Immunohistochemistry
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概要
- 論文の詳細を見る
The proliferative potentials of intracranial meningiomas, as represented by bromodeoxyuridine (BrdU) labeling index (LI) and MIB-1 staining index (SI), were examined, and their correlation with recurrence and regrowth of meningiomas was reviewed. The mean BrdU LI of recurrent meningiomas was reported to be significantly higher than that of nonrecurrent meningiomas. BrdU LI can predict the time to re-operation. Many studies have been conducted to examine the relationship between MIB-1 SI and clinical outcome of meningiomas, and most of them showed a significant relationship. Time interval to next recurrence in recurrent meningiomas is associated with MIB-1 SI, and several investigators have shown a cut-off point for MIB-1 SI that can predict future recurrence. BrdU LI, MIB-1 SI, and tumor doubling time of intracranial meningiomas have a mutual relationship. While many other biological or genetic variables can affect the proliferation of tumors, nevertheless BrdU LI and MIB-1 SI are closely correlated with clinical recurrence or regrowth of meningiomas.
- 日本組織細胞化学会の論文
著者
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Osamura Yoshiyuki
Department of Pathology Tokai University School of Medicine
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MATSUNO Akira
Department of Neurosurgery, Teikyo University Chiba Medical Center
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NAKAGUCHI Hiroshi
Department of Neurosurgery, Teikyo University Chiba Medical Center
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Fujimaki Takamitsu
Department Of Neurosurgery Teikyo University Itabashi Hospital
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Fujimaki Takamitsu
帝京大学医学部附属市原病院 脳神経外科学
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Fujimaki Takamitsu
Department Of Neurosurgery
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Osamura Y
Department Of Pathology Tokai University School Of Medicine
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Osamura R
Department Of Pathology School Of Medicine Tokai University
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Nagashima Tadashi
Department of Neurosurgery, Teikyo University Ichihara Hospital
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Matsuno A
Department Of Neurosurgery Teikyo University Ichihara Hospital
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Matsuno Akira
帝京大学ちば総合医療センター 脳神経外科
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Matsuno Akira
Department Of Biological Science Faculty Of Life And Environmental Science Shimane University
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Matsuno Akira
Department Of Neurosurgery Teikyo University Chiba Medical Center
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Matsuno Akira
Department Of Life Science Graduate School Of Natural Science And Technology Kanazawa University
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Osamura Yoshiyuki
Department Of Pathology Tokai University School Of Of Medicine
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Nakaguchi Hiroshi
Department Of Neurosurgery Teikyo University Chiba Medical Center
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Nakaguchi Hiroshi
Department Of Neurosurgery Teikyo University Ichihara Hospital
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Nagashima Tadashi
Department Of Baioscience And Biotechnology Shinshu University
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Aida Masato
Department Of Life Science Graduate School Of Natural Science And Technology Kanazawa University
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Osamura Y
Department Of Pathology Tokai University School Of Of Medicine
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Nagashima T
Teikyo Univ. School Of Medicine Ichihara Hospital
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Osamura Yoshiyuki
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
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Osamura Yoshiyuki
Department Of Internal Medicine Tokai University School Of Medicine
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Matsuno Akira
Department Of Neurosurger Teikyo University Chiba Medical Center
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Nakaguchi Hiroshi
Department Of Neurosurger Teikyo University Chiba Medical Center
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