Activity and Distribution of Histidine Decarboxylase and Histamine Concentration in Rat Stomach
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概要
- 論文の詳細を見る
The involvement of histamine in mediating gastric function under normal and pathological conditions has been largely established. Histidine decarboxylase (HDC) is the only synthetic enzyme of histamine in the mast cell or enterochromaffin like (ECL) cell. In this study, we examined, the activity of HDC by a method based on the modification of Kobayashi's method, the histological distribution of HDC containing cells was determined by an immunohistochemical method and the histamine concentration by a HPLC method in rat stomach. Histamine concentration in the total gastric layer of the fundus is overwhelming large compared to that in the antrum. On the other hand, histamine concentration of the mucosal layer of the fundus is 72.1±0.4μg/g (mean±S. D.) and that in both the muscular and serosal layers is 7.2±0.4μg/g. HDC activity of the total gastric layer of the fundus was about ten times as high as that in the antrum. Histological distribution of HDC-containing endocrine cells was observed in the basal part of the gastric mucosa of the fundus, but could not be observed in the muscular and serosal layer. These results suggest that HDC-containing endocrine cells, in only the basal parts of the mucosal layer of the fundus, were similar to ECL cells and have important parts for biosynthesis of internal gastric histamine. Therefore, using the total gastric layer of the stomach was thought to be easier than using only the mucosal layer for measuring gastric histamine and HDC-activity in rats.
- 東海大学の論文
著者
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Osamura Yoshiyuki
Department of Pathology Tokai University School of Medicine
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Miwa Takeshi
Department Of Internal Medicine School Of Medicine Tokai University
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KONAGAYA Minoru
Department of Internal Medicine, Tokai University School of of Medicine
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HARASAWA Shigeru
Department of Internal Medicine, Tokai University School of of Medicine
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MATSUMOTO Masahiko
Department of Biochemistry, School of Medicine, Tokai University
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HARA Masafumi
Department of Internal Medicine, School of Medicine, Tokai University
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Osamura R
Department Of Pathology School Of Medicine Tokai University
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Miwa Masahiko
Department Of Internal Medicine School Of Medicine Tokai University
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Miwa Masahiko
Department Of Biochemistry School Of Medicine Tokai University
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Miura T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miwa T
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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Miwa Masahiko
Endoscopic Center School Of Medicine Tokai University
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Osamura Yoshiyuki
Department Of Pathology Tokai University School Of Of Medicine
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Matsumoto Masahiko
Department Of Biochemistry School Of Medicine Tokai University
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Matsumoto M
Department Of Biochemistry School Of Medicine Tokai University
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Mitomi Toshio
Second Department Of Surgery Tokai University School Of Medicine
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Miwa Takeshi
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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Hara Masafumi
Department Of Internal Medicine School Of Medicine Tokai University
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Osamura Yoshiyuki
Department Of Surgery Tokai University School Of Medicine
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Harasawa Shigeru
Department Of Internal Medicine School Of Medicine Tokai University
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Harasawa Shigeru
Division Of Gastroenterology Ii Tokai University School Of Medicine
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Harasawa Shigeru
Department Of Gastroenterology Ii Tokai University School Of Medicine
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Osamura Yoshiyuki
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
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Miwa Takeshi
Department Of Internal Medicine 6 Tokai University School Of Medicine
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Osamura Yoshiyuki
Department Of Internal Medicine Tokai University School Of Medicine
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Miura T
Department Of Internal Medicine School Of Medicine Tokai University
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Konagaya Minoru
Department Of Internal Medicine Tokai University School Of Of Medicine
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