Ultrastructural Studies in 4-aminopyrazolopyrimidine (4-APP)-Induced Fatty Liver
スポンサーリンク
概要
- 論文の詳細を見る
Ultrastructural alterations of 4-aminopyrazolopyrimidine (4-APP)-induced fatty liver were studied. Light microscopically, liver sections after 3 to 5 days of 4-APP administration demonstrated more extensive fatty changes and highly osmiophilic lipid droplets were mainly observed in the portal zones of the lobules. The most striking ultrastructural alterations were seen in the Golgi complexes and rough endoplasmic reticulum. Golgi complexes were markedly dilated and osmiophilic vesicles were noted near the Golgi complexes. In the rough endoplasmic reticulum, dilatation of cisternae, loss of the parallel arrangement and dilated vesicles, most of which contained diminished numbers of ribosomes, were also seen. In addition, degranulation of rough endoplasmic reticulum was observed. However, no remarkable changes were noted in the mitochondira. Based on these findings, the functional state of the organellae concerned was discussed.
- 東海大学の論文
著者
-
Osamura Yoshiyuki
Department of Pathology Tokai University School of Medicine
-
Osamura R
Department Of Pathology School Of Medicine Tokai University
-
Watanabe K
Aoba Gakuen
-
Watanabe Keiichi
Department Of Internal Medicine School Of Medicine Tokai University
-
MURAKOSHI Masanori
Departments of Pathology, School of Medicine, Tokai University
-
Osamura Y
Department Of Pathology Tokai University School Of Of Medicine
-
Murakoshi M
(present Address)products Strategy Dcpartment Pharma Business Strategy Division Teikoku Hormone Mfg.
-
Murakoshi Masanori
Department Of Pathology School Of Medicine Tokai University
-
Osamura Yoshiyuki
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
-
Osamura Yoshiyuki
Department Of Internal Medicine Tokai University School Of Medicine
-
Watanabe Keiichi
Department Of Applied Biological Science Faculty Of Agriculture Saga University
関連論文
- OI-02 Evaluated of 3D Imaging of Tumor Angiogenesis in Estrogeninduced Prolactinoma and its Inhibitory Effect by Anti-VEGF antibody in Rats
- S3-03 Recent progress in laser capture microdissection for molecular histology(Advanced Histochemistry)
- S3-03 Recent progress in laser capture microdissection for molecular histology(Advanced Histochemistry)
- An Up-to-Date Anti-Cancer Treatment Strategy Focusing on HIF-1α Suppression : Its Application for Refractory Ovarian Cancer
- An Up-to-Date Anti-Cancer Treatment Strategy Focusing on HIF-1α Suppression : Its Application for Refractory Ovarian Cancer
- Effect of perinatal exposure to diethylstilbestrol (DES) on mammary differentiation and tumorigenesis in female rats(Endocrine system, Proceedings of the 32nd Annual Meeting)
- Effect of perinatal exposure to diethylstilbestrol (DES) on mammary differentiation and tumorigenesis in female rats(Endocrine system, Proceedings of the 32nd Annual Meeting)
- PI-23 Immunohistochemical localization of DCAMLK1 on rat and mouse pancreas
- The Role of Histamine in Ethanol-Induced Gastric Mucosal Injury in the Rat
- Activity and Distribution of Histidine Decarboxylase and Histamine Concentration in Rat Stomach
- Acute Pancreatitis and Cushing's Disease
- I-B-01 An application of immunohistochemistry and cytochemistry imaging : Three dimensional analysis of nano crystal (Q dot) labeled antibody by confocal laser scanning microscopy (CLSM) and immunoelectronmicroscopy (IEM)(THE 45TH ANNUAL MEETING OF THE JA
- Simultaneous Detection of DAB and Methyl Green Signals on Apoptotic Nuclei by Confocal Laser Scanning Microscopy
- P3-18 Immunohistochemical Localization of a Subtilisin-like Protease PACE 4 in Rat Pancreas
- Prohormone convertases (PC1/3 and PC2) in rat and human pancreas and islet cell tumors : Subcellular immunohistochemical analysis
- Mechanism of Hormone Production in Pituitary Cells and Pituitary Neoplasms; Synergistic Actions of Transcription Factors (Symposium IRegulation of Endocrine Function)
- Functional Differentiation and its Regulation in Pituitary Cells (Recent Progress In Gene Histochemistry)
- P-56 Immunohistochemical Detection of Rab 3 Protein in the Pituitary Glands of the Rat Species and the GH-RH Transgenic Rat
- Improved ultrastructural double staining method of rat growth hormone and its mRNA using LR White resin
- Subcellular organelle analysis applying confocal laser scanning microscopy to the steroid-producing epithelial ovarian tumor : A technical note
- Leiomyoma of the Lung : Report of a Case
- Gastric Carcinoma with Lymphoid Stroma : Clinicopathological Studies of Four Cases
- The Role of Actin in Changes of Cell Shape and Steroidogenesis in Mouse Y-1 Cells Stimulated by ACTH : Immunocytochemical Studies
- Ovarian carcinomas with neuroendocrine differentiation : Review of five cases referring to immunohistochemical characterization
- Expression of Carbohydrate Antigens (SSEA-1, Sialyl-Lewis X, DU-PAN-2 and CA19-9) and E-selectin in Urothelial Carcinoma of the Renal Pelvis, Ureter, and Urinary Bladder
- IIB-01 Expression of Hypoxia-related markers, GLUT-1 and HIF-1 alpha, in the ovarian tumors : association with histology and tumor grade(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- IA-20 Expression analysis of Cocaine- and amphetamine-regulated transcript (CART), leptin, orexin and neuropeptide Y in the smoking-treated rat pituitary and hypothalamus(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- II-C-28 Effects of smoking on expression of Cocaine-and Amphetamine-Regulated Transcript(CART) peptides(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- I-C-23 Significance of GLUT-1 expression as a differential and biological marker in thyroid gland tumors(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- P-47-C Expression of cytokeratins(cytokeratin7 and cytokeratin20) in the ovarian mucinous cancers and colorectal cancers(THE JOINT MEETING OF THE 44TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY AND THE 35TH ANNUAL MEETING OF T
- P-24-B LOH alterations associated with progestene administration in endometrial hyperplasia and adenocarcinoma(THE JOINT MEETING OF THE 44TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY AND THE 35TH ANNUAL MEETING OF THE CLINICA
- Gelatinolytic localization of gynecologic tumors Applying in situ zymography
- A-25 Putative Roles of Lysosomal Enzymes in Nuclei DNA Degradation Induced in Rat Hepatocytes by Carbon Tetrachloride (CC14)
- A Case of Epithelioid Hemangioendothelioma Associated with an Artery
- Follow-up Laparoscopy in Patients with Ovarian Cancer
- Double squamous cell carcinomas, verrucous type and poorly differentiated type, of the urinary bladder unassociated with biharzial infection
- Histopathological Analyses of Proliferative Potentials of Intracranial Meningiomas Using Bromodeoxyuridine and MIB-1 Immunohistochemistry
- Utility of Confocal Laser Scanning Microscopy (CLSM) : With Reference to Interpretation in Immunostaining
- Availability of CD10 as a Histopathological Diagnostic Marker
- Usefulness of laser capture microdissection for analysis of nucleic acids(THE SIXTH JAPAN-CHINA JOINT SEMINAR ON HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Evaluation of HER2 Status: For the Treatment of Metastatic Breast Cancers by Humanized Anti-HER2 Monoclonal Antibody (Trastuzumab) (Pathological Committee for Optimal Use of Trastuzumab)
- A Case of Macroprolactinoma with Subclinical Growth Hormone Production
- Primary sclerosing lipogranuloma with broad necrosis of the scrotum
- IA-28 3D imaging of secretory granules pathway in GH3 cell line(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- S3-3 Applications of quantum dot (Qdot) for immunoelectronmicroscopy using confocal laser scanning microscopic spectrum analysis(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- S2-4 Suppression of Hormone Expression through the silencing of pituitary-specific transcription factor by RNA interference(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Two- or Three-Dimensional Imagings of Simultaneous Visualization of Rat Pituitary Hormone and Its mRNA : Comparison between Electron Microscopy and Confocal Laser Scanning Microscopy with Semiconductor Nanocrystals (Quantum dots)
- II-B-04 Observation of pituitary hormone and its mRNA using nanocrystal (Quantum dot) under confocal laser scanning microscopy(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Pit-1 Gene Inhibition Using Small Interfering RNAs in Rat Pituitary GH Secreting Cell Line
- Electron microscopic and confocal laser scanning microscopic observation on morphological alterations of Rab3B and GH expression in rat pituitary cells induced by growth hormone releasing hormone and somatostatin
- Confocal Laser Scanning Microscopic Imaging of Subcellular Organelles, mRNA, Protein Products, and the Microvessel Environment
- P-36 Selective staining of double stranded DNA by methyl green (MG) : A study using DNA transfer membrane
- Functional Interpretation of the Kidney Juxtaglomerular Apparatus Using Renin Immunohistochemistry in Bartter's, Pseudo-Bartter's and Conn's Syndromes
- Ultrastructural and Biochemical Studies in Human Adrenocortical Adenomas Associated with Primary Aldosteronism
- Enzyme Histo-cytochemical Studies in Human Adrenocortical Adenomas [II] Cushing's Syndrome
- Enzyme Histocytochemical Studies in Human Adrenocortical Adenomas : [I] Primary aldosteronism
- Three-Dimensional (3D) Imaging of Tumor Angiogenesis and its Inhibition : Evaluation of Tumor Vascular-Targeting Agent Efficacy in the DMBA-induced Rat Breast Cancer Model by Confocal Laser Scanning Microscopy (CLSM)
- Prognostic Parameters in Axillary Node Negative Breast Cancer
- Immunohistochemical Localization of Glutathione Reductase (GSSG-RD) in Rat Fetus and Newborn
- Compassionate Use of Humanized Anti-HER2/neu Protein, Trastuzumab for Metastatic Breast Cancer in Japan
- IA-25 Studies on regulated secretion pathway in GH3 stable cell line expressing EYFP-GH fusion protein(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Application of Ultrastructural In Situ Hybridization Combined with Immunohistochemistry to Pathophysiological Studies of Pituitary Cell: Technical Review (Recent Progress In Gene Histochemistry)
- P7-53 Effect of various dose of estrogen on mammary cell proliferation and tumorigenesis in normal and tumor-induced rats(ENDOCRINE AND NERVOUS SYSTEM)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Expression of Prolactin Gene in Spontaneous Mammary Tumors in Aging Fischer 344 Rats
- Molecular and Histological Studies of Pituitary Tumorigenesis Using Experimental Animal Models
- 29-II-10 Breakthrough of immuno-fluorescence antibody method using the nano crystal particle by fluorescence microscopy(FM), confocal laser scanning microscopy(CLSM), and immunoelectronmicroscopy(EM)(THE JOINT MEETING OF THE 44TH ANNUAL MEETING OF THE JAP
- Inflammatory Carcinoma of the Breast: Characteristic Findings of MR Imaging
- Mechanism of Human chorionic gonadotropin(HCG) Secretion in Accelerated BeWo cells
- ULTRASTRUCTURAL LOCALIZATION OF HCG AND SUBUNITS IN THE HUMAN PLACENTA AND CHORIOCARCINOMA CELL LINES-MORPHOLOGICAL APPROACH TO SECRETORY PATHWAY
- Immunoelectron microscopic localization of HCG and its subunits in the human placenta and in the neoplastic trophoblasts.
- JTII-15 Blastoid variant of mantle cell lymphoma mimicking prolymphocytic leukemia
- Is it permissible to omit mediastinal dissection for peripheral non-small-cell lung cancers with tumor diameters less than 1.5 cm?
- IIA-11 Effectiveness of heat-induced antigen retrieval on immunocytochemistry using anti-estrogen receptor antibodies recognized various regions of antigen(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- I-C-04 Effect of Calcium on Heat-induced Antigen Retrieval in Immunohistochemistry : Examination by Dot-blot Analysis(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- P1-14 The Examination of the Effectiveness of Antigen Retrieval Immunohistochemistry by Dot-Blotting Method
- The intramitochondrial localization of GSH-Peroxidase(GSH-PO) in rat hepatocytes : effect of 4-aminopyrazolopyrimidine(4-APP) and Streptozotocin(STZ)
- CORRELATION BETWEEN INTRAMITOCHONDRIAL LOCALIZATION OF GLUTATHIONE-PEROXIDASE (MITOCHONDRIAL GSH-PO) AND STEROIDOGENESIS IN THE RAT ADRENOCORTICAL CELLS
- CHARACTERISTIC IMMUNOCYTOCHEMICAL LOCALIZATION OF GLUTATHIONE-PEROXIDASE (GSH-PO) IN RAT TESTICULAR INTERSTITIAL MACROPHAGES
- IMMUNOHISTO-CYTOCHEMICAL LOCALIZATION OF GLUTATHIONE-PEROXIDASE (GSH-PO) IN THE RAT TESTIS
- Heterogeneity of immunocytochemical localization of Glutathione peroxidase(GSH-PO) in the rat adrenocortical cells : Cytosol and Mitochondria
- Enzyme Histochemical and Ultrastructural Studies in Human Adrenal Glands of Normal and Anencephalic Fetuses
- Enzyme Histo-cytochemical Studies in Human Fetal Adrenal Glands
- B-7 A study for Cell Origin and Differentiation of Neuroendocrine cells, Using Germ cell tumors of the Human Testis
- Prognostic Factors for Node-Negative Breast Cancers: Results of a Study Program by the Japanese Breast Cancer Society
- Small cell neuroendocrine carcinoma of the rectum
- IMMUNOCYTOCHEMICAL LOCALIZATION OF GLUTATHIONE-PEROXIDASE (GSH-PO) IN THE RAT OVARY
- Ultrastructural Studies in 4-aminopyrazolopyrimidine (4-APP)-Induced Fatty Liver
- Ultrastructural localization of glutathione peroxidase (GSH-PO) in the rat ovary.
- Endoscopic Criteria for Invasive Depth of Superficial Esophageal Cancer
- Tokai Medical Information System : Retrieval of Medical Records and Information System for Pathological Diagnoses
- LOCALIZATION OF ANTERIOR PITUITARY HORMONES ON EPON SECTIONS BY PEROXIDASE-LABELED ANTIBODY METHOD : LIGHT AND ELECTRON MICROSCOPIC OBSERVATIONS
- IA-30 The expression analysis in the pituitaries of Prop1 transgenic mice(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- A-14 Expression of Corticotropin eleasing hormone (CRH), CRH receptor (CRH-R) and Proopiomelanocortin (PONC) in human skin.
- Rhabdomyosarcoma of the Prostate : Report of a Case with an Immunohistochemical Study of the Neoplastic Rhabdomyoblast
- Reticular crypt epithelium and intra-epithelial lymphoid cells in the hyperplastic human palatine tonsil : An immunohistochemical analysis
- Ubiquitinated cytokeratin inclusions in lichen amyloidosus : An immunohistochemical analysis
- Immunoreactive Pit-1 Protein in Hyperplastic Pars Intermedia Induced by Calcitonin of the Rat Pituitary Gland
- Immunohistochemical Studies of Early Changes of Pituitary Glands Induced by Synthetic Salmon Calcitonin (sCT) jn Sprague-Dawley Rats : Experimental Models for the Human Alpha-Subunit-Producing Pituitary Adenomas
- Antigen retrieval for bcl-2 protein in formalin-fixed, paraffinembedded sections
- A Case of Adenoid Squamous Cell Carcinoma of the Breast Skin