CYCLIC CHANGES OF ALKALINE PHOSPHATASE IN THE HUMAN ENDOMETRIUM : HISTOCHEMICAL AND BIOCHEMICAL ANALYSES
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概要
- 論文の詳細を見る
The changes of the endometrial alkaline phosphatase (ALP) along with menstrual cycles were investigated by both enzyme histochemistry and biochemistry. In order to avoid biassed views which may come mostly from insufficient observation on the limited number of cases, the endometrial specimens were obtained from over 180 patients without known abnormalities. Very fine cyclic changes of the ALP, including changes of the intracellular localization pattern, were clearly evidenced by histochemical observations, which were intimately substantiated by biochemical assay. In the proliferative phase, the ALP activity gradually increased to reach its peak at the early secretory phase, right after ovulation. In the mid to late secretory phase, a rather abrupt decrease of the enzyme was evidenced by an inverse increase of the mucin secretion which could be observed by alcian blue staining. On the basis of this clear cyclic change of the endometrial ALP, the mode of hormonal regulation, either by estrogen or by progesterone, on the enzyme activity was discussed.
- 日本組織細胞化学会の論文
著者
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Watanabe Keiichi
Department Of Internal Medicine School Of Medicine Tokai University
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Suzuki Mitsuaki
Department Of Obstetrics And Gynecology Jichi Medical College
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KURAMOTO Hiroyuki
Department of Clinical Cytology, Graduate School of Medical Scieces, Kitasato University
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Suzuki Mitsuaki
Department Of Obstetrics And Gynecology Jichi Medical School
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Suzuki Mitsuaki
Department Of Chemistry Graduate School Of Material Science Josai University
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IZUMI Shinichi
Department of Pathology, School of Medicine, Tokai University
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SHIRANE HIDEO
Department of Pathology, School of Medicine, Tokai University
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Kuramoto Hiroyuki
Department Of Clinical Cytology Graduate School Of Medical Scieces Kitasato University:department Of
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Kuramoto Hiroyuki
Department Of Obstetrics And Gynecology School Of Medicine Kitasato University
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Shirane Hideo
Department Of Pathology School Of Medicine Tokai University
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Izumi Shinichi
Department Of Pathology School Of Medicine Tokai University
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Watanabe Keiichi
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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Watanabe Keiichi
Department of Pathology, Tokai University School of Medicine
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Kuramoto Hiroyuki
Department of Obstetrics and Gynecology, School of Medicine, Kitasato University
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