Suppression of Messenger Ribonucleic Acid for Glutathione Peroxidase in Chemically Induced Rat Hepatocellular Carcinoma and its Biological Significance
スポンサーリンク
概要
- 論文の詳細を見る
Deviations of the enzyme activity, immunoreactivity and messenger ribonucleic acid (mRNA) levels of glutathione peroxidase (GSH-PO) in 3'-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma of the rat were investigated. Enzyme activities of GSH-PO were significantly lower in hepatocellular carcinomas than those in the normal control rat liver. Immunohistochemically, GSH-PO was strongly localized in normal hepatocytes, but was only faintly stained in hepatocelllular carcinoma cells. Heterogenous staining patterns of GSH-PO were observed among individual cancer cells. In Northern blot analysis, GSH-PO mRNA in the cancer tissue was decreased to two thirds of the level in normal hepatocytes. It was suggested that suppressed expression of GSH-PO in carcinogen-induced hepatocellular carcinomas occurred at the level of mRNA transcription.
- 東海大学の論文
著者
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Takekoshi Susumu
Department of Pathology, Tokai University School of Medicine
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Takekoshi S
Department Of Pathology School Of Medicine Tokai University
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Watanabe K
Aoba Gakuen
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Watanabe Keiichi
Department Of Internal Medicine School Of Medicine Tokai University
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SHINODA Masayuki
Department of Rehabilitation Service, Aichi Cancer Center Hospital
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Shinoda Masayuki
Department Of Pathology School Of Medicine Tokai University:division Of Surgery Haga Red Cross Hospi
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LERTPRASERTSUKE Nirush
Department of Pathology, School of Medicine, Tokai University
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YOSHIMURA Shinichi
Research Laboratory of Cell Biology, School of Medicine, Tokai University
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Takekoshi Susumu
Department Of Pathodiagnostics Course Of Basic Clinical Science Tokai University School Of Medicine
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Yoshimura Shinichi
Departments Of Cell Biology Tokai University School Of Medicine
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Yoshimura S
Department Of Molecular Life Science (cell Biology Division) Tokai University School Of Medicine
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Lertprasertsuke N
Department Of Pathology School Of Medicine Tokai University
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Lertprasertsuke Nirush
Department Of Pathology Chiang Mai University
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Watanabe Katsuto
Department Of Pathology School Of Medicine Tokai University
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Watanabe Keiichi
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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